11-Hydroperoxy-12,13-epoxy-9-octadecenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-Hydroperoxy-12,13-epoxy-9-octadecenoic acid
• 英文别名: (E)-11-hydroperoxy-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
• 化学式: C₁₈H₃₂O₅
• 分子量: 328.4
• InChiKey: LSLYTZURYMOJBX-JLHYYAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] THERAPEUTIC FRACTIONS AND PROTEINS FROM ASTHMA-PROTECTIVE FARM DUST<br/>[FR] FRACTIONS ET PROTÉINES THÉRAPEUTIQUES ISSUES DE POUSSIÈRE DE FERME PROTECTRICE CONTRE L'ASTHME
  申请人：UNIV ARIZONA

  公开号：WO2021158990A1

  公开（公告）日：2021-08-12

  The present invention relates to the asthma-protective effects of farm dust, specifically to a composition comprising barn dust extract including isolated fractions of an Amish barn dust extract comprising different bioactive components that have an ability to protect against asthma. In particular, the present invention describes a barn dust composition with asthma-protective properties, the barn dust composition comprising one or more bioactive fractions extracted from barn dust, said one or more bioactive fractions comprising one or more proteins and one or more fatty acids. The one or more bioactive fractions of the barn dust compositions may comprise molecular weights of 30-100 kDa, particularly 28-64 kDA, that include eight (8) target proteins, which have potential to proactively prevent the induction of asthma and to treat current cases of asthma. The present invention also relates to an in vitro method for screening allergic compounds.