dichlorodihydro[N,N'-bis(2-methoxybenzylideneethylenediamine)copper(II)] | 1455011-09-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: dichlorodihydro[N,N'-bis(2-methoxybenzylideneethylenediamine)copper(II)]
• 英文别名: copper;1-(2-methoxyphenyl)-N-[2-[(2-methoxyphenyl)methylideneamino]ethyl]methanimine;dichloride;dihydrate
• CAS: 1455011-09-2
• 化学式: C₁₈H₂₄Cl₂CuN₂O₄
• 分子量: 466.852
• InChiKey: PEXNACYBSANWAN-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N,N'-bis(2-methoxybenzylidene)ethylenediamine 、 铜 以 乙醇 、 水 为溶剂， 反应 2.0h， 以91%的产率得到dichlorodihydro[N,N'-bis(2-methoxybenzylideneethylenediamine)copper(II)]
  参考文献：
  名称：

  Thermal studies, structural characterization, and antimicrobial evaluation of coordinated metal complexes containing salen moiety

  摘要：

  Using the bidentate ligand N,N'-bis(2-methoxybenzylidene)ethylenediamine salen Schiff base, Cu(II), Cr(III), and La(III) complexes were prepared and structurally characterized using several physicochemical techniques. The thermal behavior of the synthesized complexes was investigated using simultaneous thermogravimetry (TG) and differential thermal analysis (DTA) techniques. The geometrical configurations of the complexes are proposed to be octahedral. Antimicrobial and antifungal activities of the reported complexes were tested and evaluated in vitro using modified Kirby-Bauer disc diffusion and minimum inhibitory concentration methods. The prepared complexes show remarkable antimicrobial activity; in particular, the Cr(III) complex exhibits potential inhibition against Escherichia coli, Staphylococcus aureus, and Candida albicans. On the other hand, the lanthanum complex presents higher in vitro antimicrobial activity when compared with the copper complex. In vitro antimicrobial activity assays indicate that the novel complexes might serve as promising candidates for new therapeutic agents.

  DOI：

  10.1007/s00706-013-1049-9