(2R)-N'-hydroxy-N-[(2S)-3-(5H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-N'-hydroxy-N-[(2S)-3-(5H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
• 化学式: C₂₀H₂₈N₄O₄
• 分子量: 388.5
• InChiKey: SVPQWSUSBRNQBI-DYVFJYSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  120
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• REDUCING FIBROSIS USING MATRIX METALLOPROTEINASE INHIBITORS
  申请人：Fisher Gary J.

  公开号：US20100178259A1

  公开（公告）日：2010-07-15

  Methods and compositions to prevent scarring of the skin include a matrix metalloproteinase inhibitor and a vehicle suitable for topical application. Scarring and damage to the epidermis and extracellular matrix may be reduced and/or prevented. Following skin damage, application of the matrix metalloproteinase inhibitor reduces expansion of the extracellular matrix portion of the skin compared to untreated skin.