(S)-2-Amino-N-[(S)-1-(4-nitro-phenylcarbamoyl)-ethyl]-3-phenyl-propionamide | 69079-68-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-Amino-N-[(S)-1-(4-nitro-phenylcarbamoyl)-ethyl]-3-phenyl-propionamide
• 英文别名: L-Phenylalanyl-N-(4-nitrophenyl)-L-alaninamide；(2S)-2-amino-N-[(2S)-1-(4-nitroanilino)-1-oxopropan-2-yl]-3-phenylpropanamide
• CAS: 69079-68-1
• 化学式: C₁₈H₂₀N₄O₄
• 分子量: 356.381
• InChiKey: YOYHYXWVWISGKD-LRDDRELGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  L-丙氨酸4-硝基酰苯胺 在 polymer-bound carbodiimide 、 1-羟基苯并三唑 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 8.17h， 生成 (S)-2-Amino-N-[(S)-1-(4-nitro-phenylcarbamoyl)-ethyl]-3-phenyl-propionamide
  参考文献：
  名称：

  Polymer-assisted solution-phase parallel synthesis of dipeptide p-nitroanilides and dipeptide diphenyl phosphonates

  摘要：

  This letter describes the parallel synthesis of dipeptide p-nitroanilides (1) and dipeptide diphenyl phosphonates (2). compounds that can be used as Substrates and irreversible inhibitors for the rapid profiling of dipeptidyl peptidases. A polymer-assisted solution-phase synthesis was used for a rapid and clean Coupling between easily available building blocks. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01954-2

文献信息

• Saliva test for hemolytic streptococcus
  申请人：Mosher E. Leroy

  公开号：US20050272113A1

  公开（公告）日：2005-12-08

  A reagent for the detection of an extracellular enzymatically active protein produced by a beta-hemolytic streptococcus bacteria found in a host biological fluid includes a proteinaceous substrate or a cholesterol-containing membrane substrate for the extracellular protein. The substrate is nonspecific within the groups of beta-hemolytic streptococcus bacterium and is in contact with an inert solid matrix. Upon reaction between the streptococcus enzymatically activate protein and the substrate, a color change discernable by an unaided human eye results. Extracellular streptococcus protein found in saliva represents a less invasive source of biological fluid for the determination as to whether a host suffers acute pharyngitis.

  一种用于检测β-溶血性链球菌产生的细胞外酶活性蛋白的试剂 链球菌 一种用于检测宿主生物液体中的β-溶血性链球菌产生的胞外酶活性蛋白的试剂，包括用于胞外蛋白的蛋白基质或含胆固醇的膜基质。底物在 β-溶血性链球菌群中是非特异性的。 链球菌 细菌群内是非特异性的，并与惰性固体基质接触。当 链球菌 酶活化蛋白与底物发生反应后，会产生肉眼可识别的颜色变化。细胞外 链球菌 唾液中的蛋白质是一种入侵性较低的生物液体来源，可用于确定宿主是否患有急性咽炎。
• KIT FOR DETECTION OF HEMOLYTIC STREPTOCOCCUS
  申请人：Bell Craig J.

  公开号：US20080220462A1

  公开（公告）日：2008-09-11

  A reagent is provided for the detection of an exotoxin protein produced by a beta-hemolytic streptococcus bacteria suspected of being present in a host biological fluid collected from a subject. An enzyme inhibitor is present to inhibit rogue protein modification of the substrate to prevent a false positive result of the color change. A kit is provided that is readily usable by an untrained user and merely requires that an element of the kit be contacted with a biological sample and thereafter no further actions are required by the user before a discernable color change is observed with visible or UV light and a positive/negative results reference card.
• METHOD TO DETECT HEMOLYTIC STREPTOCOCCUS AND OPTOELECTRICALLY DETERMINE RESULTS
  申请人：Bell Craig J.

  公开号：US20110045515A1

  公开（公告）日：2011-02-24

  A reagent is provided for the detection of an exotoxin protein produced by a betahemolytic streptococcus bacteria suspected of being present in a host biological fluid collected from a subject. A kit is provided that is readily usable by an unskilled user and merely requires that an element of the kit be contacted with a biological sample and that element is then subjected to electromagnetic spectral energy. The incident electromagnetic spectral energy then reacts with the exotoxin protein indicator and can be reliably measured by an electromagnetic spectral emission. The emission is measured by a reporting module and is displayed to the user in a form recognized by the user's sensory systems; sight, sound, etc. or a combination thereof.
• US7316910B2
  申请人：——

  公开号：US7316910B2

  公开（公告）日：2008-01-08
• US9115382B2
  申请人：——

  公开号：US9115382B2

  公开（公告）日：2015-08-25