(Z)-1-(biphenyl-4-yl)-2-(1'H-spiro[cyclopentane-1,2'-quinazoline]-4'(3'H)-ylidene)ethanone | 1271450-46-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-1-(biphenyl-4-yl)-2-(1'H-spiro[cyclopentane-1,2'-quinazoline]-4'(3'H)-ylidene)ethanone
• 英文别名: (2Z)-1-(4-phenylphenyl)-2-spiro[1,3-dihydroquinazoline-2,1'-cyclopentane]-4-ylideneethanone
• CAS: 1271450-46-4
• 化学式: C₂₆H₂₄N₂O
• 分子量: 380.489
• InChiKey: GTCZPCATOAHGIL-MOHJPFBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 三乙烯二胺 、 三甲氧基磷 作用下， 以 二甲基亚砜 为溶剂， 以0.81 g的产率得到(Z)-1-(biphenyl-4-yl)-2-(1'H-spiro[cyclopentane-1,2'-quinazoline]-4'(3'H)-ylidene)ethanone
  参考文献：
  名称：

  One-Pot Eschenmoser Episulfide Contractions in DMSO: Applications to the Synthesis of Fuligocandins A and B and a Number of Vinylogous Amides

  摘要：

  Practical total syntheses of the natural products fuligocandin A (2a) and fuligocandin B (3) have been achieved through a convergent strategy depending on the Eschenmoser episulfide contraction as a key step. Conducting the reaction in DAIS proved to be an efficient and general method for the synthesis of a variety of vinylogous amides, such as azepan-2-ylidenepropan-2-one.

  DOI：

  10.1021/jo101864n

文献信息

• One-Pot Eschenmoser Episulfide Contractions in DMSO: Applications to the Synthesis of Fuligocandins A and B and a Number of Vinylogous Amides
  作者：Birgitta Pettersson、Vedran Hasimbegovic、Jan Bergman

  DOI：10.1021/jo101864n

  日期：2011.3.18

  Practical total syntheses of the natural products fuligocandin A (2a) and fuligocandin B (3) have been achieved through a convergent strategy depending on the Eschenmoser episulfide contraction as a key step. Conducting the reaction in DAIS proved to be an efficient and general method for the synthesis of a variety of vinylogous amides, such as azepan-2-ylidenepropan-2-one.