Win64338;Win-64338

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Win64338;Win-64338
• 英文别名: tributyl-[[4-[[2-[(N,N'-dicyclohexylcarbamimidoyl)amino]-3-naphthalen-2-ylpropanoyl]amino]phenyl]methyl]phosphanium;chloride;hydrochloride
• 化学式: C45H69Cl2N4OP
• 分子量: 783.9
• InChiKey: YYJGBEZPVOUBMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.93
• 重原子数：
  53
• 可旋转键数：
  20
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  65.5
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries
  申请人：IMBA-Institut für Molekulare Biotechnologie GmbH

  公开号：EP1723962A1

  公开（公告）日：2006-11-22

  The invention relates to the use of Angiotensin converting enzyme 2 (ACE2) for the preparation of a medicament for the treatment of severe acute lung injury, especially induced by acid aspiration or sepsis, of lung oedemas and lung injuries and failures connected with infection with severe acute respiratory syndrome (SARS) coronavirus.

  本发明涉及利用血管紧张素转换酶 2（ACE2）制备一种药物，用于治疗严重急性肺损伤，特别是由吸酸或败血症引起的肺损伤、肺水肿以及与严重急性呼吸系统综合征（SARS）冠状病毒感染有关的肺损伤和衰竭。
• Bradykinin receptor antagonists and uses thereof
  申请人：Pretorius Mias

  公开号：US20070032409A1

  公开（公告）日：2007-02-08

  The present invention regards bradykinin receptor antagonists for treatment of a medical condition. In particular, the medical condition follows cardiopulmonary bypass. In specific embodiments, bradykinin receptor antagonists are used for the treatment of protamine-induced hypotension and/or fibrinolysis.
• Use of Inhibitors of the Renin-Angiotensin System for the Treatment of Lung Injuries
  申请人：Penninger Josef

  公开号：US20080159962A1

  公开（公告）日：2008-07-03

  The invention relates to the use of Angiotensin Converting enzyme 2 (ACE2) for the preparation of a medicament for the treatment of severe acute lung injury, especially induced by acid aspiration or sepsis, of lung oedemas and lung injuries and failures connected with infection with severe acute respiratory Syndrome (SARS) Coronavirus.
• US6500831B1
  申请人：——

  公开号：US6500831B1

  公开（公告）日：2002-12-31
• US6531480B1
  申请人：——

  公开号：US6531480B1

  公开（公告）日：2003-03-11