5Z,8Z,11Z,14Z-octadecatetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5Z,8Z,11Z,14Z-octadecatetraenoic acid
• 英文别名: (5Z,8Z,11Z,14Z)-octadeca-5,8,11,14-tetraenoic acid
• 化学式: C₁₈H₂₈O₂
• 分子量: 276.4
• InChiKey: UCHYLNQKIYPHBX-GJDCDIHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Injectable solution at pH 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
  申请人：ADOCIA

  公开号：US10449256B2

  公开（公告）日：2019-10-22

  The invention relates to a composition in the form of an injectable aqueous solution, the pH of which is between 6.6 and 7.8, including at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) a hydrophobized anionic polymer. In one embodiment, the compositions according to the invention also include a prandial insulin.

  本发明涉及一种可注射水溶液形式的组合物，其 pH 值介于 6.6 和 7.8 之间，至少包括： a) 基础胰岛素，其等电点 pI 介于 5.8 和 8.5 之间；以及 b) 疏水性阴离子聚合物。在一个实施方案中，根据本发明的组合物还包括胰岛素。
• INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN THE ISOELECTRIC POINT OF WHICH IS COMPRISED IN 5.8 AND 8.5 AND AN ANIONIC COMPOUND BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS
  申请人：ADOCIA

  公开号：US20140235536A1

  公开（公告）日：2014-08-21

  A composition in the form of an injectable aqueous solution, the pH of which is from 6.6 to 7.8, comprises at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) an anionic compound bearing carboxylate charges and hydrophobic radicals. The composition may also include a prandial insulin.
• INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN THE ISOELECTRIC POINT OF WHICH IS BETWEEN 5.8 AND 8.5 AND A HYDROPHOBIZED ANONIC POLYMER
  申请人：ADOCIA

  公开号：US20140249079A1

  公开（公告）日：2014-09-04

  The invention relates to a composition in the form of an injectable aqueous solution, the pH of which is between 6.6 and 7.8, including at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) a hydrophobized anionic polymer. In one embodiment, the compositions according to the invention also includes a prandial insulin.
• INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN THE ISOELECTRIC POINT OF WHICH IS BETWEEN 5.8 AND 8.5 AND A HYDROPHOBIZED ANIONIC POLYMER
  申请人：ADOCIA

  公开号：US20150314003A2

  公开（公告）日：2015-11-05

  The invention relates to a composition in the form of an injectable aqueous solution, the pH of which is between 6.6 and 7.8, including at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5; and b) a hydrophobized anionic polymer. In one embodiment, the compositions according to the invention also include a prandial insulin.