2E,6E,8E,10E-dodecatetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2E,6E,8E,10E-dodecatetraenoic acid
• 英文别名: (2E,6E,8E,10E)-dodeca-2,6,8,10-tetraenoic acid
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.25
• InChiKey: ASTBWPMXGJCVAM-IFZPDKMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD FOR PRODUCING SANSHOOL
  申请人：Aoki Katsuyuki

  公开号：US20130245303A1

  公开（公告）日：2013-09-19

  Provided are a method for producing a sanshool, which method has a short process and exhibits high stereoselectivity, as well as an iron carbonyl complex compound that is an intermediate useful for the production method. A diene iron complex compound characterized by being represented by the following general formula (I): (in which A represents CO, P(R A ) 3 , CN, NO, SO(R A ) 3 , or N(R A ) 2 ; R A represents a straight chain or branched chain alkyl group having 1 to 4 carbon atoms or an aryl group having 6 to 12 carbon atoms; and one of R 1 and R 2 represents a hydrogen atom and the other one thereof represents a structure represented by the following formula (II)): (in which R represents a hydrogen atom, a hydroxyl group, or a methyl group).

  提供一种生产花椒醇的方法，该方法具有简短的过程并表现出高立体选择性，以及一种铁羰基络合物化合物，该化合物是用于生产方法的中间体。一种二烯铁络合物化合物，其特征在于由以下一般式(I)表示：（其中A代表CO、P(RA)3、CN、NO、SO(RA)3或N(RA)2；RA代表具有1至4个碳原子的直链或支链烷基基团或具有6至12个碳原子的芳基基团；R1和R2中的一个代表氢原子，另一个代表以下式(I)表示的结构）：（其中R代表氢原子、羟基或甲基）。
• PHARMACEUTICAL COMPOSITION AND METHODS
  申请人：Lipocine Inc.

  公开号：EP3185873A1

  公开（公告）日：2017-07-05
• Extracts of Curcuma and Methods of Use Thereof
  申请人：Alberte Randall S.

  公开号：US20100098788A1

  公开（公告）日：2010-04-22

  The present invention relates in part to turmeric extracts that are useful for treating or preventing neurodegenerative disorders. Another aspect of the invention relates in part to turmeric extracts that are useful for treating or preventing inflammatory disorders. In some embodiments, the extracts comprise at least one compound selected from the group consisting of 25 to 500 μg bamosamine, 25 to 750 μg echinaxanthol, 100 to 3,000 μg bisdemethoxycurcumin, 50 to 500 μg daphniyunnine E and 500 to 75,000 μg curcumin per 100 mg of extract. Another aspect of the invention relates to pharmaceutical compositions comprising the aforementioned extracts. Another aspect of the invention relates to methods of treating or preventing neurodegenerative disorders comprising administering to a subject in need thereof an effective amount of the aforementioned extracts or compositions. Another aspect of the invention relates to methods of making the aforementioned extracts.
• (17-ß)-3-OXOANDROST-4-EN-17-YL UNDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
  申请人：Lipocine Inc.

  公开号：US20160193225A1

  公开（公告）日：2016-07-07

  Disclosed herein are compositions having a lipophilic active agent and methods of their use.
• (17-ß)-3-Oxoandrost-4-En-17-Yl Undecanoate Compositions and Methods of Their Preparation and Use
  申请人：Lipocine Inc.

  公开号：US20180104257A1

  公开（公告）日：2018-04-19

  Disclosed herein are compositions having a lipophilic active agent and methods of their use.