5,11-Octadecadienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5,11-Octadecadienoic acid
• 英文别名: (5E,11E)-octadeca-5,11-dienoic acid
• 化学式: C₁₈H₃₂O₂
• 分子量: 280.4
• InChiKey: GMEOMWBQHUIYIE-SCCLZRITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Fatty acid phenolic conjugates
  申请人：——

  公开号：US20040254357A1

  公开（公告）日：2004-12-16

  This invention relates to a biologically active formulation containing a conjugate of a fatty acid and a complex phenol. The fatty acid can be selected from a variety of fatty acids including acids have between 12 and 24 carbon atoms. The phenol can be a polynuclear phenol, a polyphenol or a polyfunctional phenol having a variety of substituents. The formulation can include pharmaceutically acceptable carrier, including diluent. The formulation can be provided in an active dosage form suitable to inhibit mammalian cell growth and/or metastasis of malignant cells. The formulation can be used to induce cytotoxicity in mammalian cells particularly tumor cells or to treat and prevent cellular injury or dysfunction.

  本发明涉及一种含有脂肪酸和复杂酚的结合物的生物活性配方。脂肪酸可以从多种含有12至24个碳原子的脂肪酸中选择。酚可以是多核酚、多酚或具有多种取代基的多功能酚。该配方可以包括药用可接受的载体，包括稀释剂。该配方可以以适合抑制哺乳动物细胞生长和/或恶性细胞转移的活性剂量形式提供。该配方可用于诱导哺乳动物细胞特别是肿瘤细胞的细胞毒性，或治疗和预防细胞损伤或功能障碍。
• Lipid formulations containing bioactive fatty acids
  申请人：SCIADONICS, INC.

  公开号：US11058656B2

  公开（公告）日：2021-07-13

  Provided herein is technology relating to lipid compositions containing bioactive fatty acids and particularly, but not exclusively, to compositions containing defined ratios of 5,11,14-eicosatrienoic acid to one or more of: 5,9,12-octadecatrienoic acid; 7,11,14-eicosatrienoic acid; 5,8,11,14-eicosatetraenoic acid; 9,12-octadecadienoic acid; 9-octadecenoic acid; 14-methyl hexadecanoic acid; 11,14 eicosadienoic acid, 5,9-octadecadienoic acid; 5,11-octadecadienoic acid; 9,12,15-octadecatrienoic acid; 5,8,11,14,17-eicosapentaenoic acid; 7,10,13,16,19-docosapentaenoic acid; and 4,7,10,13,16,19-docosahexaenoic acid.

  本文提供的技术涉及含有生物活性脂肪酸的脂质组合物，特别是（但不限于）含有确定比例的 5,11,14-二十碳三烯酸与下列一种或多种物质的组合物：5,9,12-octadecatrienoic acid; 7,11,14-eicosatrienoic acid; 5,8,11,14-eicosatetraenoic acid; 9,12-octadecadienoic acid; 9-octadecenoic acid; 14-methyl hexadecanoic acid; 11,14-eicosadienoic acid, 5,9-octadecadienoic acid；5,11-十八碳二烯酸；9,12,15-十八碳三烯酸；5,8,11,14,17-二十碳五烯酸；7,10,13,16,19-二十碳五烯酸；以及 4,7,10,13,16,19-二十二碳六烯酸。
• LIPID FORMULATIONS CONTAINING BIOACTIVE FATTY ACIDS
  申请人：SCIADONICS, INC.

  公开号：US20180353453A1

  公开（公告）日：2018-12-13

  Provided herein is technology relating to lipid compositions containing bioactive fatty acids and particularly, but not exclusively, to compositions containing defined ratios of 5,11,14-eicosatrienoic acid to one or more of: 5,9,12-octadecatrienoic acid; 7,11,14-eicosatrienoic acid; 5,8,11,14-eicosatetraenoic acid; 9,12-octadecadienoic acid; 9-octadecenoic acid; 14-methyl hexadecanoic acid; 11,14 eicosadienoic acid, 5,9-octadecadienoic acid; 5,11-octadecadienoic acid; 9,12,15-octadecatrienoic acid; 5,8,11,14,17-eicosapentaenoic acid; 7,10,13,16,19-docosapentaenoic acid; and 4,7,10,13,16,19-docosahexaenoic acid.
• [EN] LIPID FORMULATIONS CONTAINING BIOACTIVE FATTY ACIDS<br/>[FR] FORMULATIONS LIPIDIQUES CONTENANT DES ACIDES GRAS BIOACTIFS
  申请人：SCIADONICS INC

  公开号：WO2017091647A1

  公开（公告）日：2017-06-01

  Provided herein is technology relating to lipid compositions containing bioactive fatty acids and particularly, but not exclusively, to compositions containing defined ratios of 5,11,14-eicosatrienoic acid to one or more of: 5, 9, 12-octadecatrienoic acid; 7, 11, 14-eicosatrienoic acid; 5, 8, 11, 14-eicosatetraenoic acid; 9, 12-octadecadienoic acid; 9-octadecenoic acid; 14-methylhexadecanoic acid; 11, 14 eicosadienoic acid, 5, 9-octadecadienoic acid; 5, 11-octadecadienoic acid; 9, 12, 15-octadecatrienoic acid; 5,8,11,14,17-eicosapentaenoic acid; 7,10,13,16,19-docosapentaenoic acid; and 4,7,10,13,16,19-docosahexaenoic acid.