20-Oxo-heneicosanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 20-Oxo-heneicosanoic acid
• 英文别名: 20-oxohenicosanoic acid
• 化学式: C₂₁H₄₀O₃
• 分子量: 340.5
• InChiKey: MAGPQMMJCMNJQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• POLYPEPTIDES
  申请人：NOVO NORDISK A/S

  公开号：US20130281363A1

  公开（公告）日：2013-10-24

  The invention relates to polypeptides comprising an amino acid sequence which is an analogue of human amylin, pharmaceutical compositions comprising these polypeptides, and these polypeptides for use as medicaments.

  这项发明涉及包括人类淀粉样蛋白类似物的氨基酸序列的多肽，包括这些多肽的药物组合物，以及这些多肽作为药物使用。
• Long-Acting Y2 and/or Y4 Receptor Agonists
  申请人：Østergaard Søren

  公开号：US20110275559A1

  公开（公告）日：2011-11-10

  The present invention relates to a PYY or PP peptide derivative or analogue thereof derivatised with one or more serum albumin binding side chains comprising a dis-tal tetrazole or carboxylic acid group. Moreover, the invention relates to compositions hereof and methods of treatment of conditions responsive to Y receptor modulation.

  本发明涉及一种与一种或多种血清白蛋白结合侧链衍生物或类似物衍生物化合的PYY或PP肽衍生物，其中包括一个远端四唑基或羧酸基团。此外，本发明涉及这些组合物以及对于对Y受体调节敏感的病况的治疗方法。
• PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES
  申请人：Madsen Peter

  公开号：US20110105720A1

  公开（公告）日：2011-05-05

  Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.

  具有对蛋白酶抵抗力的新型酰化胰岛素类似物可以通过肺部或口服有效地给予。胰岛素类似物包含B25H和A14E或A14H。
• PROTEASE STABILIZED ACYLATED INSULIN ANALOGUES
  申请人：NOVO NORDISK A/S

  公开号：US20150210748A1

  公开（公告）日：2015-07-30

  Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.

  具有对蛋白酶抗性的新型酰化胰岛素类似物可以有效地通过肺部或口服给药。胰岛素类似物包含B25H和A14E或A14H。
• METHOD FOR PRODUCING CARBOXYLIC ACID
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP1544190A1

  公开（公告）日：2005-06-22

  The present invention provides a safe, convenient and efficient method for producing carboxylic acid by a reaction of alicyclic alcohol with an aqueous hydrogen peroxide to thereby obtain carboxylic acid in high yield from alicyclic alcohol or alicyclic ketone under mild reaction conditions, wherein the reaction operation is simple and easy, a step for removing solvent after completion of the reaction is not necessary and influence and toxicity upon the environment and human body are markedly small. In order to provide it, an oily alicyclic alcohol is allowed to react with an aqueous hydrogen peroxide in the presence of a catalyst containing a metal compound belonging to Group 6 of the Periodic Table in a heterogeneous solution system.

  本发明提供了一种安全、方便、高效的生产羧酸的方法，该方法通过脂环醇与过氧化氢水溶液反应，从而在温和的反应条件下，从脂环醇或脂环酮中高产率地获得羧酸，反应操作简单易行，反应完成后无需去除溶剂的步骤，对环境和人体的影响和毒性明显较小。为了实现这一目标，需要在一个异相溶液体系中，在含有元素周期表第 6 族金属化合物的催化剂存在下，使油性脂环醇与过氧化氢水溶液发生反应。