D-Ileu | 28112-78-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-Ileu
• 英文别名: (2R,3R)-2-amino-3-methylhexanoic acid
• CAS: 28112-78-9
• 化学式: C₇H₁₅NO₂
• 分子量: 145.202
• InChiKey: KWSUGULOZFMUDH-PHDIDXHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Acetyl-D-Ileu 在 sodium hydroxide 、 prozyme acylase 作用下， 生成 D-Ileu
  参考文献：
  名称：

  New Method for the Separation of Diastereomeric Mixtures of β-Methylnorleucine and β-Methylleucine

  摘要：

  β-甲基正亮氨酸和β-甲基亮氨酸被合成、分离成差向异构体并进行光学解析。这些异构体的构型分配以及光学活性异构体的确定分别通过核磁共振波谱学和酶学方法实现。

  DOI：

  10.1246/bcsj.43.1541

文献信息

• Asymmetric β‐Methylation of <scp>l</scp> ‐ and <scp>d</scp> ‐α‐Amino Acids by a Self‐Contained Enzyme Cascade
  作者：Cangsong Liao、Florian P. Seebeck

  DOI：10.1002/anie.201916025

  日期：2020.4.27

  AbstractThis report describes a modular enzyme‐catalyzed cascade reaction that transforms l‐ or d‐α‐amino acids to β‐methyl‐α‐amino acids. In this process an α‐amino acid transaminase, an α‐keto acid methyltransferase, and a halide methyltransferase cooperate in two orthogonal reaction cycles that mediate product formation and regeneration of the cofactor pyridoxal‐5′‐phosphate and the co‐substrate S‐adenosylmethionine. The only stoichiometric reagents consumed in this process are the unprotected l‐ or d‐α‐amino acid and methyl iodide.
• New Method for the Separation of Diastereomeric Mixtures of β-Methylnorleucine and β-Methylleucine
  作者：Kazuo Okubo、Yoshiharu Izumi

  DOI：10.1246/bcsj.43.1541

  日期：1970.5

  β-Methylnorleucine and β-methylleucine were synthesized, separated into diastereomers and optically resolved. The configurational assignments of these isomers and the determinations of the optically active isomers were achieved by means of NMR spectroscopy and the enzymatic method respectively.

  β-甲基正亮氨酸和β-甲基亮氨酸被合成、分离成差向异构体并进行光学解析。这些异构体的构型分配以及光学活性异构体的确定分别通过核磁共振波谱学和酶学方法实现。