US9180183, Quinidine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: US9180183, Quinidine
• 英文别名: (S)-[(5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
• 化学式: C₂₀H₂₄N₂O₂
• 分子量: 324.4
• InChiKey: LOUPRKONTZGTKE-QPWZMSJCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  45.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Cinchona alkaloid derivatives, their process of preparation and their use as catalysts
  申请人：Fundació Privada Institut Català d'Investigació Química (ICIQ)

  公开号：EP2687527A1

  公开（公告）日：2014-01-22

  The present invention provides a process for preparing a substantially stereochemically pure compound of formula (I), or a salt thereof wherein R1 and R2 are independently selected from the group consisting of H, -CH2-CH3, and -CH=CH2, the process comprising the step of demethylating the corresponding methylated compound of formula (II) in the presence of an alkaline or alkaline earth metal (C1-C10) alkylthiolate salt and a polar aprotic solvent.

  本发明提供了一种制备式(I)化合物或其盐的方法，其中R1和R2独立地选自H，-CH2-CH3和-CH=CH2的群，该方法包括在碱性或碱土金属（C1-C10）烷硫酸盐和极性无水溶剂的存在下脱甲基化式(II)的相应甲基化合物的步骤。
• Sensor and method of detecting an analyte using 19F NMR
  申请人：Massachusetts Institute of Technology

  公开号：US10620143B2

  公开（公告）日：2020-04-14

  A sensor including a fluorinated receptor can be used to identify an analyte through shift in 19F NMR resonance of the receptor when the receptor interacts with the analyte.

  包括含氟受体的传感器可用于在受体与分析物相互作用时，通过受体 19F NMR 共振的移动来识别分析物。
• Compositions and methods for modulating gated ion channels
  申请人：Babinski Kazimierz

  公开号：US20070004680A1

  公开（公告）日：2007-01-04

  The present invention relates to compositions and methods to modulate the activity of gated ion channels.
• US9776961B2
  申请人：——

  公开号：US9776961B2

  公开（公告）日：2017-10-03
• [EN] COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS<br/>[FR] COMPOSITIONS ET METHODES DE MODULATION DES CANAUX IONIQUES COMMANDES PAR PORTE
  申请人：PAINCEPTOR PHARMA CORP

  公开号：WO2006038070A2

  公开（公告）日：2006-04-13

  The present application relates to compositions which modulate the activity of gated ion channels. This provide an effect in the treatment of pain, inflammatory disorders and neurological disorders. Preferred compounds include quinine or quinidine derivatives with the hydroxyl at the nine position being esterified with an aliphatic carboxylic acid, optionally bearing an additional cycloalkyl ring on the chain. The gated ion channels modulated include homomultimeric and heteromultimeric gates.