(Acetylamino-methyl)-carbamic acid tert-butyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Acetylamino-methyl)-carbamic acid tert-butyl ester
• 英文别名: Tert-butyl N-(acetamidomethyl)carbamate
• 化学式: C₈H₁₆N₂O₃
• 分子量: 188.227
• InChiKey: VWULWTOZRRUIPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Acetylamino-methyl)-carbamic acid tert-butyl ester 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 生成 N-(aminomethyl)acetamide
  参考文献：
  名称：

  Secondary Effects in Flexible Hydrogen Bonding Networks

  摘要：

  Extension of Jorgensen's secondary interaction hypothesis to conformationally flexible systems has been examined. The results indicate that secondary interactions between covalently adjacent hydrogen bonding groups are as important as secondary interactions between hydrogen bonding groups brought together by the primary interactions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00333-5
• 作为产物：
  描述：

  N-乙酰甘氨酸 、 叔丁醇 在 二苯基膦叠氮化物 、 三乙胺 作用下， 反应 24.0h， 以41%的产率得到(Acetylamino-methyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Secondary Effects in Flexible Hydrogen Bonding Networks

  摘要：

  Extension of Jorgensen's secondary interaction hypothesis to conformationally flexible systems has been examined. The results indicate that secondary interactions between covalently adjacent hydrogen bonding groups are as important as secondary interactions between hydrogen bonding groups brought together by the primary interactions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00333-5

文献信息

• Conjugates of Immune Cell Specific Macrolide Compounds with Anti-Inflammatory Compounds for Improved Cellular Targeting of Anti-Inflammatory Therapy
  申请人：MERCEP Mladen

  公开号：US20090105163A1

  公开（公告）日：2009-04-23

  The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.

  本发明涉及一类由结构式I表示的新化合物及其制药制剂，用于治疗人和动物的炎症性疾病。
• US7446097B2
  申请人：——

  公开号：US7446097B2

  公开（公告）日：2008-11-04
• US7928078B2
  申请人：——

  公开号：US7928078B2

  公开（公告）日：2011-04-19
• [EN] POLYMERS, HYDROGELS, AND USES THEREOF<br/>[FR] POLYMÈRES, HYDROGELS ET UTILISATIONS ASSOCIÉES
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2016154317A2

  公开（公告）日：2016-09-29

  Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., (aa)) and polyol-containing moieties (e.g., (bb)) are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.
• Secondary Effects in Flexible Hydrogen Bonding Networks
  作者：Robb R Gardner、Samuel H Gellman

  DOI：10.1016/s0040-4020(97)00333-5

  日期：1997.7

  Extension of Jorgensen's secondary interaction hypothesis to conformationally flexible systems has been examined. The results indicate that secondary interactions between covalently adjacent hydrogen bonding groups are as important as secondary interactions between hydrogen bonding groups brought together by the primary interactions. (C) 1997 Elsevier Science Ltd.

表征谱图