(2R,4R,5R)-5-[(1S)-1-acetamido-3-methylbutyl]-4-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,4R,5R)-5-[(1S)-1-acetamido-3-methylbutyl]-4-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid
• 化学式: C₁₅H₂₃N₃O₃S
• 分子量: 325.4
• InChiKey: DMMOSNCHCAZGNV-YVECIDJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES
  申请人：Abbott Laboratories

  公开号：EP1358154A2

  公开（公告）日：2003-11-05
• [EN] Inhibitors of neuraminidases
  申请人：ABBOTT LAB

  公开号：WO2001028996A2

  公开（公告）日：2001-04-26

  Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.