4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)cyclohexane-1-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)cyclohexane-1-carboxamide
• 英文别名: 4-amino-N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]cyclohexane-1-carboxamide
• 化学式: C₁₈H₂₆N₄O₂S₂
• 分子量: 394.6
• InChiKey: MFPWMKHFMBARRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  148
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy
  申请人：——

  公开号：US20020061915A1

  公开（公告）日：2002-05-23

  The invention provides a method for preventing or treating alopecia induced by chemotherapy or radiotherapy by administering to a mammalian specie in need thereof a therapeutically effective amount of a compound of formula I or II 1 or a pharmaceutically acceptable salt thereof.

  该发明提供了一种方法，通过向需要的哺乳动物物种施用化学式I或II1的化合物或其药用可接受盐的治疗有效量，预防或治疗由化疗或放疗引起的脱发。
• Compositions and methods for the treatment of cancer
  申请人：——

  公开号：US20030114504A1

  公开（公告）日：2003-06-19

  The compounds of the invention are protein kinase inhibitors and are useful in the treatment of proliferative diseases. Compositions and methods are provided for the synergistic treatment of proliferative disorders.

  本发明的化合物是蛋白激酶抑制剂，可用于治疗增殖性疾病。本发明提供了用于协同治疗增殖性疾病的组合物和方法。
• [EN] N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]-CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES<br/>[FR] INHIBITEURS CONTENANT N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]CARBOXAMIDE INHIBANT DES KINASES DEPENDANTES DES CYCLINES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2001044242A1

  公开（公告）日：2001-06-21

  The present invention describes compounds of formula (I): and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula (I) compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, chemotherapy-induced alopecia, and cardiovascular disease.

  本发明描述了公式（I）的化合物及其对映体、非对映异构体和药学上可接受的盐。公式（I）化合物是蛋白激酶抑制剂，可用于治疗增殖性疾病，例如癌症、炎症和关节炎。它们还可以用于治疗阿尔茨海默病、化疗诱导的脱发和心血管疾病。
• Pharmaceutical combination comprising a CDK inhibitor and a VEGF receptor inhibitor
  申请人：Schering Aktiengesellschaft

  公开号：EP1568368A1

  公开（公告）日：2005-08-31

  Pharmaceutical combinations comprising at least one compound of general formula (I): and at least one compound of general formula (II): and/or of general formula (IIa): and/or of general formula (IIb): and their use for the treatment of different diseases.

  包含至少一种通式(I)化合物的药物组合物： 和至少一种通式 (II) 和/或通式 (IIa) 和/或通式（IIb）的化合物： 以及它们在治疗不同疾病中的用途。
• N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1240166A1

  公开（公告）日：2002-09-18