N-nitrosopiperidine appears as light yellow oil or liquid. May be a carcinogen.
颜色/状态：
Yellow oil
蒸汽压力：
9.20X10-2 mm Hg at 20 °C
稳定性/保质期：
Stable at room temp for more than 14 days in neutral or alkaline soln in dark; less stable in acidic soln; light-sensitive, especially to ultra-violet light
分解：
When heated to decomposition it emits toxic fumes of ... /nitrogen oxides/.
N-Nitrosopiperidine was oxidized by rat liver microsomes to 4-hydroxynitrosopiperidine. Administration of (3)H N-nitrosopiperidine or deuterated N-nitrosopiperidine to rats led to reaction with DNA and RNA in the liver, but the products were not characterized.
/A study was conducted with/ urinary metabolites of N-nitrosopiperidine, 3- and N-nitrosohexamethyleneimine and N-nitroso-heptamethyleneimine. ... The percentage of the dose excreted as metabolites in the urine increased with ring size. Hydroxy and ketone derivatives of all three of the N-nitrosoalicyclic amines were found. ... No glutaric acid was found from N-nitrosopiperidine.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
没有关于人类的数据。动物中有充分的致癌性证据。总体评估：2B组：该物质可能对人类有致癌性。
No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
N-亚硝基哌啶：合理预期为人类致癌物。
N-Nitrosopiperidine: reasonably anticipated to be a human carcinogen.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌物分类
国际癌症研究机构致癌物：N-亚硝基哌啶
IARC Carcinogenic Agent:N-Nitrosopiperidine
来源:International Agency for Research on Cancer (IARC)
毒理性
致癌物分类
国际癌症研究机构（IARC）致癌物分类：2B组：可能对人类致癌
IARC Carcinogenic Classes:Group 2B: Possibly carcinogenic to humans
来源:International Agency for Research on Cancer (IARC)
毒理性
致癌物分类
国际癌症研究机构专著：第17卷：（1978年）一些N-亚硝基化合物
IARC Monographs:Volume 17: (1978) Some N-Nitroso Compounds
来源:International Agency for Research on Cancer (IARC)
(3)H N-nitrosopiperidine injected into the bladder of rats or Syrian golden hamsters was absorbed, and radioactivity was found in the liver and kidneys of both species and in the stomach, small intestine and lungs of hamsters
... Nitrosamines ... can presumably cross the placenta since they are capable of inducing neoplasma in the offspring if administered to rats in late pregnancy. /Nitrosamines/
Male mice were each administered iv 1.2 mg/kg (6.0-7.6 muCi) of (14)C-labeled nitrosopiperidine (NPIP) and frozen by immersion in dry ice/hexane at 0.1, 0.33, 1, 3, 9, and 24 hr after injection. The mice were processed for whole-body autoradiography without thawing or the use of any solvents; sagittal sections of the frozen mice were freeze-dried and placed on x-ray film to reveal areas of localization of radioactivity. The autoradiographs revealed intense localization of radioactivity at 6 min in the epithelium of the nose and bronchi, as well as in the liver, kidney, and salivary glands. There is virtually no affinity of NPIP for melanin. Most of the same localizations persisted from 6 min through 24 hr. At 24 hr, the most intense accumulation was in the epithelium of the bronchi, nose, salivary gland ducts, and esphagus as well as the liver and Harder's gland. Thus, a greater than or equal metabolite of NPIP which localizes in the sites where tumors occur may be similar to a metabolite of N'-nitrosonornicotine. The distribution is consistent with the metabolic conversion of NPIP in the liver and epitherlium of the nose and bronchi with subsequent localization of the metabolite in the epithelium of the esphagus and salivary gland ducts.
The aim of the present study was to evaluate the effects of ascorbic acid and green tea on urinary excretion of carcinogenic N-nitrosodimethylamine and N-nitrosopiperidine in humans. Twenty-five healthy female volunteers consumed a fish meal rich in amines as nitrosatable precursors in combination with intake of nitrate-containing drinking water at the Acceptable Daily Intake level during 7 consecutive days. During 1 week before and after nitrate intake a diet low in nitrate was consumed. Using the same protocol, the effect of two different doses of ascorbic acid (250 mg and 1 g/day) and two different doses of green tea (2 g and 4 g/day) on formation of N-nitrosodimethylamine and N-nitrosopiperidine was studied. Mean nitrate excretion in urine significantly increased from control (76+/-24) to 167+/-25 mg/24 h. Intake of nitrate and fish resulted in a significant increase in mean urinary excretion of N-nitrosodimethylamine compared with the control weeks: 871+/-430 and 640+/-277 ng/24 h during days 1-3 and 4-7, respectively, compared with 385+/-196 ng/24 h (p<0.0002). Excretion of N-nitrosopiperidine in urine was not related to nitrate intake and composition of the diet. Intake of 250 mg and 1 g of ascorbic acid per day resulted in a significant decrease in urinary N-nitrosodimethylamine excretion during days 4-7 (p=0.0001), but not during days 1-3. Also, consumption of four cups of green tea per day (2 g) significantly decreased excretion of N-nitrosodimethylamine during days 4-7 (p=0.0035), but not during days 1-3. Surprisingly, consumption of eight cups of green tea per day (4 g) significantly increased N-nitrosodimethylamine excretion during days 4-7 (p=0.0001), again not during days 1-3. This increase is probably a result of catalytic effects of tea polyphenols on nitrosation, or of another, yet unknown, mechanism. These results suggest that intake of ascorbic acid and moderate consumption of green tea can reduce endogenous N-nitrosodimethylamine formation.
The invention provides a therapeutic drug for ischemic stroke. The therapeutic drug has the formula (I)
wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof, as an active ingredient.
Silicon Polonovski Reaction. Formation and Synthetic Application of α-Siloxy Amines
作者：Norihiro Tokitoh、Renji Okazaki
DOI：10.1246/bcsj.60.3291
日期：1987.9
amines with acyl halides and haloformates gave the corresponding amides and carbamates in moderate to good yields, respectively. Treatment of α-siloxy amines with acetic acid resulted in a direct dealkylation to free secondary amines. Fluoride induced alkylation of α-siloxy amines using alkyl halides as electrophiles leading to tertiaryamines was also examined and demonstrated to be a new transalkylation
Selective N-Nitrosation of Amines,<i>N</i>-Alkylamides and<i>N</i>-Alkylureasby N<sub>2</sub>O<sub>4</sub>Supported on Cross-Linked Polyvinylpyrrolidone(PVP-N<sub>2</sub>O<sub>4</sub>)
N2O4 was supported on the cross-linked polyvinylpyrrolidone (PVP) to afford a solid, stable and recyclable nitrosating agent. This reagent shows excellent selectivity for N-nitrosation of dialkyl amines in the presence of diaryl-, arylalkyl-, trialkylamines and also for secondary amides in dichloromethane at room temperature under mild and heterogeneous conditions. Also N-nitroso-N-alkyl amides can be selectively prepared in the presence of primary amides and N-phenylamides under similar reaction conditions. Selective N-nitrosation or dealkylation and N-nitrosation of tertiary amines can also be performed by this reagent.
Reactions of trifluoroamine oxide: a route to acyclic and cyclic fluoroamines and N-nitrosoamines
作者：Om Dutt Gupta、Robert L. Kirchmeier、Jean'ne M. Shreeve
DOI：10.1021/ja00162a045
日期：1990.3
Preparation de fluoroamines et de nitrosoamines secondaires acycliques R 2 NF et R 2 NNO (R=CH 3 ,C 2 H 5 ,n-C 3 H 7 ,i-C 3 H 7 ,n-C 4 H 9 ,i-C 4 H 9 ,c-C 6 H 11 ) et de fluoroamines et nitrosoamines heterocycliques satures RNF et RNNO (R=c-C 4 H 8 ,c-C 5 H 10 ,(CH 3 ) 2 -2,6-c-C 5 H 8 ,(CH 3 ) 4 -2,2,6,6-c-C 5 H 6 ) par reaction des amines correspondantes avec NF 3 O
制备去氟胺和去亚硝基胺二类无环R 2 NF 和R 2 NNO (R=CH 3 ,C 2 H 5 ,nC 3 H 7 ,iC 3 H 7 ,nC 4 H 9 ,iC 4 H 9 ,cC 6 H 11 ) et de fluoroamines et nitrosoamines 杂环饱和 RNF et RNNO (R=cC 4 H 8 ,cC 5 H 10 ,(CH 3 ) 2 -2,6-cC 5 H 8 ,(CH 3 ) 4 -2,2,6 ,6-cC 5 H 6 ) par 反应脱胺对应物 avec NF 3 O
Synthesis of N,N-dialkylnitramines from secondary ammonium nitrates in liquid or supercritical carbon dioxide
作者：I. V. Kuchurov、I. V. Fomenkov、S. G. Zlotin
DOI：10.1007/s11172-009-0282-1
日期：2009.10
An efficient explosion-proof method was developed for the preparation of N,N-dialkylnitramines by treatment of dialkylammonium nitrates with a mixture of nitric acid and acetic anhydride in the presence of ZnCl2 in liduid or supercritical carbon dioxide.
