4-[4-(1H-IMIDAZOL-1-YL)PHENYL]-1-OXO-1,2-DIHYDROPHTHALAZINE | 122853-64-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-[4-(1H-IMIDAZOL-1-YL)PHENYL]-1-OXO-1,2-DIHYDROPHTHALAZINE
• 英文别名: 4[4-(1H-imidazol-1-yl)phenyl]-1-oxo-1,2-dihydrophthalazine；4-(4-imidazol-1-ylphenyl)-2H-phthalazin-1-one
• CAS: 122853-64-9
• 化学式: C₁₇H₁₂N₄O
• 分子量: 288.308
• InChiKey: SZLNAIZZDQEMBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl-2-[4-(1H-imidazol-1-yl)benzoyl]benzoate 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 4-[4-(1H-IMIDAZOL-1-YL)PHENYL]-1-OXO-1,2-DIHYDROPHTHALAZINE
  参考文献：
  名称：

  Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and

  摘要：

  本发明涉及公式为##STR1##的咪唑基苯基和1,2,4-三唑基苯基苯并吡啶酮和吡啶并吡啶酮化合物，其中A为CH或N，且W、X、Y和Z中最多只有一个是N原子，具有有价值的制药制剂，例如增加心肌收缩力。所述化合物的用途包括增加心脏收缩力和治疗充血性心力衰竭的方法，包括它们的制药组合物和制备方法。

  公开号：

  US04806535A1

文献信息

• SMALL MOLECULE MODULATORS OF CYTOKINE ACTIVITY
  申请人：Zembower David E.

  公开号：US20100137285A1

  公开（公告）日：2010-06-03

  The present invention provides compounds having formula (I) or (II): and pharmaceutically acceptable derivatives thereof, wherein m, p, R 1 , R 2 , R 3 and R 4 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of diseases, disorders or conditions associated with HGF/SF or other cytokine activity.
• HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES
  申请人：Paka Latha

  公开号：US20100256117A1

  公开（公告）日：2010-10-07

  Methods are provided for treating fibrotic connective tissue diseases such as scleroderma and conditions such as surgically-induced adhesions using compounds that activate the signaling pathways of hepatocyte growth factor.
• ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  申请人：Oehlen Lambertus J.W.M.

  公开号：US20120190668A1

  公开（公告）日：2012-07-26

  The present invention provides methods for enhancing cellular transplantation by exposing cells in vitro or ex vivo, or a recipient of cells, to a small molecule hepatocyte growth factor/scatter factor mimetic. Exemplary compounds are described.
• ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  申请人：ANGION BIOMEDICA CORP

  公开号：US20140171419A1

  公开（公告）日：2014-06-19

  The present invention provides methods for enhancing cellular transplantation by exposing cells in vitro or ex vivo, or a recipient of cells, to a small molecule hepatocyte growth factor/scatter factor mimetic. Exemplary compounds are described.
• US4806535A
  申请人：——

  公开号：US4806535A

  公开（公告）日：1989-02-21