methyl (4Z)-1-(4-bromophenyl)-4-[(2-hydroxyphenyl)methylidene]-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: methyl (4Z)-1-(4-bromophenyl)-4-[(2-hydroxyphenyl)methylidene]-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate
• 英文别名: methyl (4Z)-1-(4-bromophenyl)-4-[(2-hydroxyphenyl)methylidene]-2-methyl-5-oxopyrrole-3-carboxylate
• 化学式: C₂₀H₁₆BrNO₄
• 分子量: 414.2
• InChiKey: QJCKCOPYBGJYBU-WJDWOHSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2
  申请人：Cardozo Timothy

  公开号：US20140142120A1

  公开（公告）日：2014-05-22

  The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity.
• COMPOSITIONS AND METHOD FOR MODULATING THE SENSITIVITY OF PLANTS TO CYTOKININ
  申请人：KIM Hyo-Jung

  公开号：US20160289698A1

  公开（公告）日：2016-10-06

  The present invention includes an expression cassette containing a polynucleotide encoding a polypeptide; and a host cell, transgenic plant (e.g., a dicot or monocot), transformed seed, and transgenic rootstock containing said expression cassette. Methods for desensitizing a plant to endogenous cytokinin; increasing seed, embryo or cotyledon size or weight; increasing the seed yield of a plant; and/or increasing the size of the root or root meristem or formation of lateral or adventitious roots are provided. In some embodiments, expression of the polypeptide is under control of a seed-preferred, embryo-preferred or root-preferred promoter.
• US9261497B2
  申请人：——

  公开号：US9261497B2

  公开（公告）日：2016-02-16
• US9796985B2
  申请人：——

  公开号：US9796985B2

  公开（公告）日：2017-10-24
• [EN] METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2<br/>[FR] MÉTHODE DE TRAITEMENT DU CANCER AVEC DES MODULATEURS DE L'ACTIVITÉ DU COMPLEXE SCF-SKP2
  申请人：UNIV NEW YORK

  公开号：WO2014062811A2

  公开（公告）日：2014-04-24

  The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity.