(S-(E,Z,Z,Z))-15-Hydroperoxy-5,8,11,13-eicosatetraenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S-(E,Z,Z,Z))-15-Hydroperoxy-5,8,11,13-eicosatetraenoic acid
• 英文别名: (5E,8E,11E,13E)-15-hydroperoxyicosa-5,8,11,13-tetraenoic acid
• 化学式: C₂₀H₃₂O₄
• 分子量: 336.5
• InChiKey: BFWYTORDSFIVKP-NLORQXDXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compounds and methods for treatment of asthma, allergy and inflammatory disorders
  申请人：UCB S.A.

  公开号：US20030220347A1

  公开（公告）日：2003-11-27

  The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

  本发明提供了1,4-取代哌嗪、1,4-取代哌啶和1-取代、4-烷基亚烯基哌啶化合物。本发明的化合物是具有白三烯抑制性和抗组胺性的双重作用分子。本发明的化合物用于治疗可能存在组胺和/或白三烯成分的病症。这些病症包括哮喘、季节性和全年性过敏性鼻炎、鼻窦炎、结膜炎、食物过敏、鲭鱼中毒、牛皮癣、荨麻疹、瘙痒、湿疹、类风湿性关节炎、炎症性肠病、慢性阻塞性肺疾病、血栓性疾病和中耳炎。还提供了通过向需要治疗哮喘和鼻炎的受试者施用有效的缓解哮喘和鼻炎的化合物量的方法。
• N-(3-butyn-1-yl) N-hydroxyurea
  申请人：UCB, S.A.

  公开号：EP1418173A1

  公开（公告）日：2004-05-12

  The present invention provides a new compound N-(3-butyn-1-yl) N-hydroxyurea.

  本发明提供了一种新化合物 N-(3-丁炔-1-基) N-羟基脲。
• Compositions and methods for measurement of analytes
  申请人：Northeastern University

  公开号：US10197498B2

  公开（公告）日：2019-02-05

  Disclosed herein sensor matrices comprising nanofibers and one or more sensor components, wherein the one or more sensor components detect an analyte. In addition, methods of making and detecting the sensor matrices are disclosed. For example, a nanofiber with a shell and coaxial core may be made with a sensor in the shell.

  本文公开了由纳米纤维和一个或多个传感器组件组成的传感器基质，其中一个或多个传感器组件可检测分析物。此外，还公开了制作和检测传感器基质的方法。例如，可以制造一种具有外壳和同轴芯的纳米纤维，在外壳中装有传感器。
• COMPOUNDS AND METHODS FOR TREATMENT OF ASTHMA, ALLERGY AND INFLAMMATORY DISORDERS
  申请人：UCB, S.A.

  公开号：EP1165533A2

  公开（公告）日：2002-01-02
• CHIMERIC PROTEINS COMPRISING A HAEM DOMAIN OF A MAMMALIAN OR PLANT CYTOCHROME P450 AND A SCAFFOLD-REDUCTASE DOMAIN FROM P450 BM3 OF BACILLUS MEGATERIUM AND USES THEREOF
  申请人：NanoBioDesign Limited

  公开号：EP1414950A2

  公开（公告）日：2004-05-06