octadec-11t-enoic acid ethyl ester | 89296-48-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: octadec-11t-enoic acid ethyl ester
• 英文别名: Octadec-11t-ensaeure-aethylester；Ethyl E-11-octadecenoate；ethyl (E)-octadec-11-enoate
• CAS: 89296-48-0
• 化学式: C₂₀H₃₈O₂
• 分子量: 310.521
• InChiKey: XZMSLYSQJNCDQH-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 锌 作用下， 生成 octadec-11t-enoic acid ethyl ester
  参考文献：
  名称：

  Effect of Dietary Omega-3 Fatty Acids and Chronic Ethanol Consumption on Reverse Cholesterol Transport in Rats

  摘要：

  We previously showed that chronic ethanol feeding reads to a decrease of apolipoprotein E (apoE) in high-density lipoprotein (HDL), whereas supplementing this diet with 2.8% of total dietary calories as omega 3-fatty acids (omega 3FAs) restores HDL-apoE to the control values. Since HDL containing apoE plays a major role in reverse cholesterol transport (RCT), we measured the effects chronic ethanol intake and omega 3-FAs -FAs on RCT in the present study. Four groups of rats, control normal fat (CN), alcohol-normal fat (AN), control omega 3FA fat (CF), and alcohol-omega 3FA fat (AF), were fed their respective diets for 8 weeks, after which hepatocytes and HDLs from each group were evaluated for RCT capacity (cholesterol efflux from macrophages end uptake by liver cells). Compared with the control diet (CN), chronic ethanol (AN) feeding inhibited the cholesterol efflux capacity of HDL by 21% (P <.01), whereas w3FA feeding (2.8% of total dietary calories) stimulated this capacity by 79% (P <.01) and 25% (P <.01) in CF and AF rats, respectively. With respect to cholesterol uptake by the liver, there were no significant 3-way or 4-way interactions between the 4 factors, HDL-alcohol, MDL-fish oil, hepatocyte-alcohol, and hepatocyte-fish oil. The main effects for HDL-alcohol, HDL-fish oil, and hepatocyte-alcohol were all highly significant (P =.0001,.0001, and .007, respectively). There was a significant HDL-alcohol and HDL-fish oil interaction (P =.0001). Hepatocyte-alcohol was not a factor in any 2-way interactions. Our study indicates no evidence of an interaction between the effects of omega 3FAs end the effects of alcohol on hepatocytes in terms of RCT function. Thus, feeding as little as 2.8% of the total dietary calories as w3FA not only restored the impaired RCT function of HDL caused by chronic ethanol intake, but also enhanced by severalfold the ability of HDL to promote RCT even in normal animals. Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0026-0495(00)80017-7

文献信息

• Novel liquid fatty acid derivatives
  申请人：NEW JAPAN CHEMICAL CO.,LTD.

  公开号：EP0713855A1

  公开（公告）日：1996-05-29

  A fatty acid derivative of formula (1) wherein each of X, Y and Z, which are the same or different, is a C₁-C₁₀ alkyloxy group or a C₃-C₁₀ cycloalkyloxy group, at least one of X, Y and Z being a C₁-C₁₀ alkyloxy group or a C₃-C₁₀ cycloalkyloxy group, each of a, b, c and d, which are the same or different, is an integer of 0 to 17 and the value of a + b + c + d is from 13 to 17; and salts thereof.

  式（1）的脂肪酸衍生物，其中X、Y和Z分别为C₁-C₁₀烷氧基或C₃-C₁₀环烷氧基，可以相同也可以不同，X、Y和Z中至少有一个为C₁-C₁₀烷氧基或C₃-C₁₀环烷氧基，a、b、c和d分别为0到17的整数，且a + b + c + d的值为13到17；以及其盐。
• PRODUCTION OF FATTY ACID DERIVATIVES
  申请人：LS9, Inc.

  公开号：EP2417246A1

  公开（公告）日：2012-02-15
• PRODUCTION OF FATTY ACID ESTERS
  申请人：Ls9, Inc.

  公开号：EP2425007A1

  公开（公告）日：2012-03-07
• [EN] PRODUCTION OF FATTY ACID DERIVATIVES<br/>[FR] PRODUCTION DE DÉRIVÉS D'ACIDE GRAS
  申请人：LS9 INC

  公开号：WO2010118410A1

  公开（公告）日：2010-10-14

  Methods and compositions for producing fatty acid derivatives, for example, fatty esters, are described.
• [EN] PRODUCTION OF FATTY ACID ESTERS<br/>[FR] PRODUCTION D'ESTERS D'ACIDES GRAS
  申请人：LS9 INC

  公开号：WO2010126891A1

  公开（公告）日：2010-11-04

  Methods of producing fatty acid esters, such as fatty acid ethyl esters, from microorganisms genetically engineered to alter the expression of genes involved in fatty acid synthesis and/or ethanol production, such that a microorganism is obtained that can produce an alcohol, a fatty acid and an ester synthase in the absence of exogenously added alcohols.