(E)-4-amino-5-methylhex-2-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-4-amino-5-methylhex-2-enoic acid
• 化学式: C₇H₁₃NO₂
• 分子量: 143.18
• InChiKey: CKELZIJSOFRBOY-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• DEVELOPMENT OF A SYNTHESIS OF SYRINGOLIN A AND B AND DERIVATIVES THEREOF
  申请人：Kaiser Markus

  公开号：US20100022767A1

  公开（公告）日：2010-01-28

  The synthesis of syringolin A and B and derivatives thereof as well as to pharmaceutical compositions containing the syringolin A or B or derivatives thereof and the use of syringolin A and B and derivatives thereof for prophylaxis and treatment of cancer.

  合成Syringolin A和B及其衍生物，以及含有Syringolin A或B或其衍生物的药物组合物的用途，以及Syringolin A和B及其衍生物用于预防和治疗癌症。
• Derivatives of syringolin A
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2210881A1

  公开（公告）日：2010-07-28

  The present invention relates to syringolin A derivatives, the use of the syringolin A derivatives for prophylaxis and treatment of neurodegenerative diseases and proliferative diseases such as cancer, pharmaceutical compositions containing at least one syringolin A derivative as well as to a synthesis for preparing the syringolin A derivatives.

  本发明涉及丝菌素A衍生物，使用丝菌素A衍生物预防和治疗神经退行性疾病和增殖性疾病，如癌症，含有至少一种丝菌素A衍生物的药物组合物，以及制备丝菌素A衍生物的合成方法。
• PHARMACEUTICAL COMPOSITIONS FOR THE TREAMENT OF CONDITIONS RESPONSIVE TO PROTEASOME INHIBITION
  申请人：Bachmann Andre S.

  公开号：US20100267070A1

  公开（公告）日：2010-10-21

  The invention disclosed herein generally relates to methods and compositions for inhibiting proteasome activity comprising a syrbactin compound have the structure of Formula (I) or (II).
• PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CONDITIONS RESPONSIVE TO PROTEASOME INHIBITION
  申请人：Pono Corporation

  公开号：US20140187526A1

  公开（公告）日：2014-07-03

  The invention disclosed herein generally relates to methods and compositions for inhibiting proteasome activity comprising a syrbactin compound having the structure of Formula I or II:
• US8597904B2
  申请人：——

  公开号：US8597904B2

  公开（公告）日：2013-12-03