[(1S,6R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: [(1S,6R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methanol
• 化学式: C₁₂H₂₀O₆
• 分子量: 260.287
• InChiKey: POORJMIIHXHXAV-WSBRJUKGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Stereoselective Glycosylation Reactions
  申请人：Trustees of Tufts College

  公开号：US20140303359A1

  公开（公告）日：2014-10-09

  Disclosed is a method for selective synthesis of 1,2-cis-α-linked glycosides which does not require the use of the specialized protecting group patterns normally employed to control diastereoselectivity. Thioglycoside acceptors can be used, permitting iterative oligosaccharide synthesis. The approach eliminates the need for lengthy syntheses of monosaccharides possessing highly specialized and unconventional protecting group patterns.

  揭示了一种选择性合成1,2-顺式α-连接的糖苷的方法，该方法不需要通常用于控制对映选择性的专门保护基团模式。可以使用硫代糖苷受体，从而允许进行寡糖合成。该方法消除了需要合成具有高度专门化和非常规保护基团模式的单糖的冗长合成过程。
• [EN] CONJUGATES OF A GLYCOPROTEIN OR A GLYCAN WITH A TOXIC PAYLOAD<br/>[FR] CONJUGUÉS D'UNE GLYCOPROTÉINE OU D'UN GLYCANE AVEC UNE CHARGE TOXIQUE
  申请人：GLYKOS FINLAND OY

  公开号：WO2014177771A1

  公开（公告）日：2014-11-06

  The invention relates to a glycoprotein-toxic pay- load molecule conjugate, a toxic payload molecule- glycan conjugate, and a pharmaceutical composi- tion.The invention further relates to a method for preparing the glycoprotein-toxic payload mole- cule conjugate, the method for modulating growth of a cell population and a method of treating tu- mour cells.

  这项发明涉及一种糖蛋白-毒性载荷分子结合物、一种毒性载荷分子-糖基结合物和一种药物组合物。该发明还涉及一种制备糖蛋白-毒性载荷分子结合物的方法，一种调节细胞群体生长的方法以及一种治疗肿瘤细胞的方法。
• Reagent-Controlled Stereoselective Glycosylation
  申请人：Trustees of Tufts College

  公开号：US20150038689A1

  公开（公告）日：2015-02-05

  Provided are methods for the efficient stereoselective formation of glycosidic bonds, without recourse to prosthetic or directing groups.

  提供了一种高效立体选择性形成糖苷键的方法，无需使用假体或定向基团。
• Drug and Imaging Agent Delivery Compositions and Methods
  申请人：UNIVERSITY OF KANSAS

  公开号：US20130189519A1

  公开（公告）日：2013-07-25

  A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical polymerization techniques, including reversible addition-fragmentation chain transfer and macromolecular design via the interchange of xanthates with a broad range of reaction conditions and functional groups. The star-shaped polymeric carriers can be tailored for preferential delivery of chemotherapeutics into the tumor-draining lymphatics via subcutaneous, peritumoral or intratumoral injections. The carriers can be loaded with the chemotherapeutic agents from about 10% to about 25% w/w. In addition, the carriers can be loaded with imaging agents from about 5% to about 10% w/w. The molecular weights of the polymeric carriers can be about 40 kDa to about 130 kDa. The chemotherapeutics can be cisplatin, geldanamycin or nitric oxide-donating prodrugs. The imaging agent can be a near-infrared dye, such as IR820.

  一种多臂星形聚合物组合物可配置用于体内药物输送和成像应用。星形聚合物结构可以使用活性自由基聚合技术合成，包括可逆加成-断裂链转移和通过与广泛的反应条件和功能基团进行黄酮交换的宏观设计。星形聚合物载体可以定制为通过皮下、肿瘤周围或肿瘤内注射将化疗药物优先输送至肿瘤引流淋巴管。载体可以装载化疗药物，负载量约为10%至25%（重量/重量）。此外，载体可以装载成像剂，负载量约为5%至10%（重量/重量）。聚合物载体的分子量可以约为40 kDa至130 kDa。化疗药物可以是顺铂、吉尔达那霉素或一氧化氮供体前药。成像剂可以是近红外染料，如IR820。
• [EN] METHOD OF PREPARATION OF α-GALACTOSYL CERAMIDES COMPOUNDS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS D'&Agr;-GALACTOSYL CÉRAMIDES
  申请人：WITTYCELL

  公开号：WO2014067995A1

  公开（公告）日：2014-05-08

  The present invention relates to a method of preparation of α-galactosyl ceramides compounds of formula (I) comprising a step a) of glycosylation of a compound of formula (II) with a compound of formula (III).

  本发明涉及一种制备α-半乳糖基鞘氨醇化合物的方法，包括以下步骤：a)将式（II）化合物与式（III）化合物进行糖基化。