2-Fluoro-benzoic acid N-tert-butyl-hydrazide | 340821-90-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Fluoro-benzoic acid N-tert-butyl-hydrazide
• 英文别名: N-tert-butyl-2-fluorobenzohydrazide
• CAS: 340821-90-1
• 化学式: C₁₁H₁₅FN₂O
• 分子量: 210.251
• InChiKey: YFRPBCZPDJLHHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Fluoro-benzoic acid N-tert-butyl-hydrazide 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 生成 N-tert-Butyl-2-fluoro-N-[3-(4-fluoro-phenyl)-2,4,5-trioxo-imidazolidin-1-yl]-benzamide
  参考文献：
  名称：

  Synthesis and biological activity of novel N ′- tert -butyl- N ′-substituted benzoyl- N -(substituted phenyl)aminocarbonylhydrazines and their derivatives

  摘要：

  Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N'-tert-butyl-N'-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01932-3
• 作为产物：
  描述：

  N'-tert-Butyl-N'-(2-fluoro-benzoyl)-hydrazinecarboxylic acid benzyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以96%的产率得到2-Fluoro-benzoic acid N-tert-butyl-hydrazide
  参考文献：
  名称：

  Synthesis and biological activity of novel N ′- tert -butyl- N ′-substituted benzoyl- N -(substituted phenyl)aminocarbonylhydrazines and their derivatives

  摘要：

  Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N'-tert-butyl-N'-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01932-3

文献信息

• A convenient synthesis ofN-t-butyl-N?-aminocarbonyl-N-(substituted)benzoyl-hydrazine containing?-aminoalkylphosphonate groups in a one-pot procedure
  作者：Qingmin Wang、Zaiguo Li、Runqiu Huang、Junran Cheng

  DOI：10.1002/hc.3

  日期：——

  for the synthesis of α-isocyanatoalkylphosphonates enjoys a number of advantages: the reaction is carried out under mild condition in good yield, triphosgene is relatively safe to handle because of its low vapor pressure and high stability, and the experimental procedure is simple. This method can be applicable to the synthesis of other α-isocyanatoalkyl-phosphonates and urylenediphosphonates. The structures

  合成了多种含有α-氨基烷基膦酸酯基团的新型N-叔丁基-N'-氨基羰基-N-（取代）苯甲酰肼。用三光气处理α-氨基烷基膦酸酯产生α-异氰酸根合烷基膦酸酯，随后加入N-叔丁基-N-取代的苯甲酰肼，在一锅法中以良好的收率提供标题化合物。三光气介导合成α-异氰酸根合烷基膦酸酯的反应具有许多优点：反应条件温和，产率高，三光气蒸汽压低，稳定性高，操作相对安全，实验步骤很简单。该方法可适用于合成其他α-异氰酸根合烷基膦酸酯和亚脲基二膦酸酯。所有产物和副产物的结构均通过1H NMR、31P NMR、IR和质谱以及元素分析证实。我们还发现一些化合物具有潜在的抗烟草花叶病毒 (TMV) 活性和抗癌活性。© 2001 John Wiley & Sons, Inc. 杂原子化学 12:68–72, 2001
• Insecticidal N'-substituted-N,N'-diacylhydrazines
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0236618A2

  公开（公告）日：1987-09-16

  This invention is concerned with insecticidal compositions containing N'-substituted-N,N'-diacylhydrazines, methods of using such compositions and with certain of the insecticidal N'-substituted-N,N'-diacylhydrazines which are novel compounds.

  本发明涉及含有 N'-取代-N,N'-二乙酰肼的杀虫组合物、使用此类组合物的方法以及某些杀虫 N'-取代-N,N'-二乙酰肼的新型化合物。
• Five-membered heterocyclic derivatives of N'-substituted-N,N'-Diacylhydrazines
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0261755A2

  公开（公告）日：1988-03-30

  Certain five-membered heterocyclic derivatives of N'- substi uted-N,N'-diacylhydrazines are insecticidally active comp sunds and may be used, optionally in compositions cont1 ning agronomically acceptable diluent or carrier, to con at insects, particularly those from the order Lepi- dop t ra.

  某些 N'-亚基-N,N'-二酰肼的五元杂环衍生物是具有杀虫活性的化合物，可用于杀灭昆虫，特别是鳞翅目昆虫，也可用于含有农艺上可接受的稀释剂或载体的组合物中。
• Six-membered heterocyclic derivatives of N'substituted-N,N'-diacylhydrazines
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0253468B1

  公开（公告）日：1991-11-06
• Organic hydrazine derivatives for pharmaceutical use
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0361645B1

  公开（公告）日：1993-09-29