4-(1-phenylmethylene-1-(N'-tert-butyldimethylsilyloxymethylcarbonyl)carboxyl-hydrazide)-piperidine-1-carboxylic acid tert-butyl ester | 676491-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1-phenylmethylene-1-(N'-tert-butyldimethylsilyloxymethylcarbonyl)carboxyl-hydrazide)-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: Tert-butyl 4-[2-[2-[2-[tert-butyl(dimethyl)silyl]oxyacetyl]hydrazinyl]-2-oxo-1-phenylethylidene]piperidine-1-carboxylate；tert-butyl 4-[2-[2-[2-[tert-butyl(dimethyl)silyl]oxyacetyl]hydrazinyl]-2-oxo-1-phenylethylidene]piperidine-1-carboxylate
• CAS: 676491-36-4
• 化学式: C₂₆H₄₁N₃O₅Si
• 分子量: 503.714
• InChiKey: HIFLZFPZZWVOMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.64
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(1-phenylmethylene-1-(N'-tert-butyldimethylsilyloxymethylcarbonyl)carboxyl-hydrazide)-piperidine-1-carboxylic acid tert-butyl ester 在 六氯乙烷 、 N,N-二异丙基乙胺 、 三苯基膦 作用下， 以 乙腈 为溶剂， 以74%的产率得到4-{[5-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,3,4]oxadiazol-2-yl]-phenyl-methylene}-piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  General synthesis of tetrasubstituted alkenyl-1,3,4-oxadiazoles

  摘要：

  Tetrasubstituted alkenyl-1,3,4-oxadiazoles were synthesized in moderate to excellent yield, under mild conditions and in the presence of sensitive functional groups, via the cyclization of diacylhydrazides using PPh3 and hexachloroethane in the presence of Hunig's base. An efficient one-pot acylation/cyclization approach for the conversion of acylhydrazides to 1,3,4-oxadiazoles is also described. The complexity of our substrate as well as the wide range of functional groups incorporated substantially broadens the scope of this methodology. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.057
• 作为产物：
  描述：

  4-(1-phenylmethylene-1-(N'-hydroxymethylcarbonyl)carboxylhydrazide)-piperidine-1-carboxylic acid tert-butyl ester 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 48.0h， 以29%的产率得到4-(1-phenylmethylene-1-(N'-tert-butyldimethylsilyloxymethylcarbonyl)carboxyl-hydrazide)-piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides

  摘要：

  这项发明提供了具有药物和生物影响性能的化合物，它们的药物组合物和使用方法。具体而言，该发明涉及具有独特抗病毒活性的新哌啶4-烯基衍生物。更具体地说，本发明涉及用于治疗艾滋病毒和艾滋病的化合物。本发明的化合物为一般式I的化合物： 1 其中： Z是 2 Q是从以下组中选择的： 3 —W—是 4

  公开号：

  US20040063744A1

文献信息

• Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
  申请人：——

  公开号：US20040063744A1

  公开（公告）日：2004-04-01

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: 1 wherein: Z is 2 Q is selected from the group consisting of: 3 —W— is 4

  这项发明提供了具有药物和生物影响性能的化合物，它们的药物组合物和使用方法。具体而言，该发明涉及具有独特抗病毒活性的新哌啶4-烯基衍生物。更具体地说，本发明涉及用于治疗艾滋病毒和艾滋病的化合物。本发明的化合物为一般式I的化合物： 1 其中： Z是 2 Q是从以下组中选择的： 3 —W—是 4
• General synthesis of tetrasubstituted alkenyl-1,3,4-oxadiazoles
  作者：Clint A. James、Brigitte Poirier、Christiane Grisé、Alain Martel、Edward H. Ruediger

  DOI：10.1016/j.tetlet.2005.11.057

  日期：2006.1

  Tetrasubstituted alkenyl-1,3,4-oxadiazoles were synthesized in moderate to excellent yield, under mild conditions and in the presence of sensitive functional groups, via the cyclization of diacylhydrazides using PPh3 and hexachloroethane in the presence of Hunig's base. An efficient one-pot acylation/cyclization approach for the conversion of acylhydrazides to 1,3,4-oxadiazoles is also described. The complexity of our substrate as well as the wide range of functional groups incorporated substantially broadens the scope of this methodology. (c) 2005 Elsevier Ltd. All rights reserved.