2-[2,4-bis(phenylamino)thiazol-5-oyl]benzothiazole | 1246090-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-[2,4-bis(phenylamino)thiazol-5-oyl]benzothiazole
• 英文别名: 1,3-Benzothiazol-2-yl-(2,4-dianilino-1,3-thiazol-5-yl)methanone
• CAS: 1246090-51-6
• 化学式: C₂₃H₁₆N₄OS₂
• 分子量: 428.538
• InChiKey: DJQCBLGYHILJLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-(1,3-苯并噻唑-2-基)-2-溴-1-乙酮 、 N-Phenylformamido-N'-phenyl-thioharnstoff 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以65%的产率得到2-[2,4-bis(phenylamino)thiazol-5-oyl]benzothiazole
  参考文献：
  名称：

  Synthesis of 2-[2,4-diaminothiazol-5-oyl]benzothiazoles

  摘要：

  Abstract magnified image The synthesis of 2‐(4‐amino‐2‐alkylaminothiazol‐5‐oyl)benzothiazoles and 2‐[2,4‐bis(arylamino)thiazol‐5‐oyl]benzothiazoles as benzothiazoloylthiazole analogs of the cytotoxic marine alkaloid dendrodoine is reported. The highly decorated thiazole ring assembly was achieved using 2‐bromoacetybenzothiazole to supply the C5 ring carbon and amidinothioureas of the type R1NHCSNHC(NHR2)(NHR3) to provide the four ring atoms [C4N3C2S1] in a [4+1] thiazole ring construction strategy. The antibacterial activity of these new analogs is reported. J. Heterocyclic Chem., (2010).

  DOI：

  10.1002/jhet.387

文献信息

• Synthesis of 2-[2,4-diaminothiazol-5-oyl]benzothiazoles
  作者：T. F. Abbs Fen Reji、Kallikat N. Rajasekharan

  DOI：10.1002/jhet.387

  日期：——

  Abstract magnified image The synthesis of 2‐(4‐amino‐2‐alkylaminothiazol‐5‐oyl)benzothiazoles and 2‐[2,4‐bis(arylamino)thiazol‐5‐oyl]benzothiazoles as benzothiazoloylthiazole analogs of the cytotoxic marine alkaloid dendrodoine is reported. The highly decorated thiazole ring assembly was achieved using 2‐bromoacetybenzothiazole to supply the C5 ring carbon and amidinothioureas of the type R1NHCSNHC(NHR2)(NHR3) to provide the four ring atoms [C4N3C2S1] in a [4+1] thiazole ring construction strategy. The antibacterial activity of these new analogs is reported. J. Heterocyclic Chem., (2010).