4-(3-chlorophenyl)-3-fluoro-6-methylpyridin-2(1H)-one | 1293293-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(3-chlorophenyl)-3-fluoro-6-methylpyridin-2(1H)-one
• 英文别名: 4-(3-chlorophenyl)-3-fluoro-6-methyl-1H-pyridin-2-one
• CAS: 1293293-12-5
• 化学式: C₁₂H₉ClFNO
• 分子量: 237.661
• InChiKey: ASDLVUGUXLCTFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(3-chlorophenyl)but-3-en-2-one 在 碳酸氢铵 、 对甲苯磺酸 、 N,N-二甲基乙二胺 、 对硝基苯甲酸 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 、 二氯甲烷 为溶剂， 生成 4-(3-chlorophenyl)-3-fluoro-6-methylpyridin-2(1H)-one
  参考文献：
  名称：

  A novel method for the synthesis of 3-fluoro-4-aryl-2-pyridone via unprecedented denitration

  摘要：

  A simple and novel method to the synthesis of 3-fluoro-4-aryl-2-pyridone from a Michael-adduct of fluoronitroacetate and alpha,beta-unsaturated ketone is reported. With (NH4)(2)CO3 as the N-source and TsOH as the promoted acid, a series of fluorinated-pyridones was obtained with moderate to good yields. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.047

文献信息

• A novel method for the synthesis of 3-fluoro-4-aryl-2-pyridone via unprecedented denitration
  作者：Xiao-Wei Wang、Hai-Feng Cui、Hai-Feng Wang、Ying-Quan Yang、Gang Zhao、Shi-Zheng Zhu

  DOI：10.1016/j.tet.2011.01.047

  日期：2011.4

  A simple and novel method to the synthesis of 3-fluoro-4-aryl-2-pyridone from a Michael-adduct of fluoronitroacetate and alpha,beta-unsaturated ketone is reported. With (NH4)(2)CO3 as the N-source and TsOH as the promoted acid, a series of fluorinated-pyridones was obtained with moderate to good yields. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.