(2-formylethyl)-4-fluorobenzamide | 1082928-21-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-formylethyl)-4-fluorobenzamide
• 英文别名: 4-fluoro-N-(3-oxopropyl)benzamide
• CAS: 1082928-21-9
• 化学式: C₁₀H₁₀FNO₂
• mdl: MFCD11610842
• 分子量: 195.193
• InChiKey: JZAOZSCNQAYCTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-formylethyl)-4-fluorobenzamide 、 环戊胺 在 Sodium triacetoxy borohydride 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 生成 N-(3-(cyclopentylamino)propyl)-4-fluorobenzamide
  参考文献：
  名称：

  N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1

  摘要：

  We report the synthesis and in vitro activity of a series of novel N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs. These analogs showed potent inhibitory activity against Kv1.3. Several compounds, including compound 8b, showed similar potency to the known Kv1.3 inhibitor PAP-1 when tested under the IonWorks patch clamp assay conditions. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.09.132
• 作为产物：
  描述：

  4-氟-N-(3-羟丙基)苯甲酰胺 在 silica gel 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以10%的产率得到(2-formylethyl)-4-fluorobenzamide
  参考文献：
  名称：

  [EN] 18 F - LABELLED 6 - ( 2 - FLUOROETHOXY) - 2 - NAPHTHALDEHYDE FOR DETECTING CANCER STEM CELLS
  [FR] 6-(2-FLUROÉTHOXY)-2-NAPHTALDÉHYDE MARQUÉ AU 18F POUR DÉTECTER DES CELLULES SOUCHES CANCÉREUSES

  摘要：

  本发明涉及针对醛脱氢酶(ALDH)的体内成像和放射治疗方法及试剂，适用于肿瘤的体内成像和癌症治疗。

  公开号：

  WO2013048832A1

文献信息

• β-Amidoaldehydes via oxazoline hydroformylation
  作者：David S. Laitar、John W. Kramer、Bryan T. Whiting、Emil B. Lobkovsky、Geoffrey W. Coates

  DOI：10.1039/b913698c

  日期：——

  4-Substituted oxazolines, which are readily synthesized from naturally occurring α-amino acids, are converted efficiently and stereospecifically to β-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl.

  易于从天然存在的α-氨基酸合成得到的4-取代噁唑啉，在合成气（CO和H2）及催化剂二钴八羰基的存在下，能够高效且立体专一性地转化为β-氨基醛。
• [EN] 18 F - LABELLED 6 - ( 2 - FLUOROETHOXY) - 2 - NAPHTHALDEHYDE FOR DETECTING CANCER STEM CELLS<br/>[FR] 6-(2-FLUROÉTHOXY)-2-NAPHTALDÉHYDE MARQUÉ AU 18F POUR DÉTECTER DES CELLULES SOUCHES CANCÉREUSES
  申请人：GE HEALTHCARE LTD

  公开号：WO2013048832A1

  公开（公告）日：2013-04-04

  The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer.

  本发明涉及针对醛脱氢酶(ALDH)的体内成像和放射治疗方法及试剂，适用于肿瘤的体内成像和癌症治疗。
• IMAGING AND RADIOTHERAPY METHODS
  申请人：Cuthbertson Alan

  公开号：US20110286922A1

  公开（公告）日：2011-11-24

  The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer.

  本发明涉及针对醛脱氢酶（ALDH）酶的体内成像和放射治疗方法和制剂，适用于肿瘤的体内成像和癌症的治疗。
• [EN] IMAGING AND RADIOTHERAPY METHODS<br/>[FR] PROCÉDÉS D'IMAGERIE ET DE RADIOTHÉRAPIE
  申请人：GE HEALTHCARE LTD

  公开号：WO2010048144A2

  公开（公告）日：2010-04-29

  The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH ) and that are suitable for the in vivo imaging of tumours and treatment of cancer.
• N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1
  作者：Curt D. Haffner、Stephen A. Thomson、Yu Guo、Lee T. Schaller、Sharon Boggs、Scott Dickerson、Jeff Gobel、Dan Gillie、J. Patrick Condreay

  DOI：10.1016/j.bmcl.2010.09.132

  日期：2010.12

  We report the synthesis and in vitro activity of a series of novel N-3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs. These analogs showed potent inhibitory activity against Kv1.3. Several compounds, including compound 8b, showed similar potency to the known Kv1.3 inhibitor PAP-1 when tested under the IonWorks patch clamp assay conditions. (C) 2010 Published by Elsevier Ltd.