N-n-propyl-2-(3-pyridyl)ethylamine | 170026-12-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-n-propyl-2-(3-pyridyl)ethylamine
• 英文别名: N-(2-pyridin-3-ylethyl)propan-1-amine
• CAS: 170026-12-7
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: ZSYZLLZPGUOFRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-n-propyl-2-(3-pyridyl)ethylamine 在 dimethyl sulfide borane 、 TEA 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N'-[2-(4-Methanesulfonyl-phenyl)-ethyl]-N-propyl-N-(2-pyridin-3-yl-ethyl)-hexane-1,6-diamine
  参考文献：
  名称：

  5,6-二羟基-2-氨基四氢萘杂环类似物的合成及其多巴胺能活性。

  摘要：

  合成了5,6-二羟基-2-氨基四氢萘的杂环类似物（6），并将其体外多巴胺能活性与（-）-DP-5,6-ADTN和新型强效激动剂Z12571进行了比较。结果表明，改变杂环的导管环会降低目标分子6的D1样活性。但是，四氢喹啉（6j）的D2样活性与（-）-DP-5,6-相当。 ADTN。

  DOI：

  10.1016/s0960-894x(00)00049-4
• 作为产物：
  描述：

  吡啶-3-乙酸甲酯 在 盐酸 、 sodium tetrahydroborate 、 sodium methylate 、 溶剂黄146 作用下， 以 苯 为溶剂， 反应 21.0h， 生成 N-n-propyl-2-(3-pyridyl)ethylamine
  参考文献：
  名称：

  New 2-pyridylethylamines with dopaminergic activity: Synthesis and radioligand-binding evaluation

  摘要：

  In order to determine whether the pyridine nucleus could replace the catechol moiety of the neurotransmitter dopamine or the phenol ring of the dopaminergic pharmacophore m-hydroxyphenylethylamine, the 2-(3-pyridyl)ethylamine 7, 2-(4-pyridyl)ethylamine 8, 2-(2-hydroxy-4-pyridyl) ethylamine 10 and their N,N-di-n-propyl- and N-n-propyl-N-2-phenylethyl derivatives were synthesized. The affinities of the new compounds for D-1 and D-2 dopamine receptors were evaluated by displacement of [H-3]SCH 23390 (D-1 selective) and [H-3]spiperone (D-2 selective) on rat neostriatum sections. The 2-(4-pyridyl)ethylamine 8 and its N,N-di-n-propyl derivative 18 showed the same affinity for the D-1 and D-2 receptors. Other compounds bound to the D-1 receptor with higher affinity than to the D-2 receptor. The possibility that the above compounds act as agonists and antagonists at the dopamine D-1 and D-2 receptors is discussed on the basis of guanosine-5'-triphosphate and Na+ displacement curves.

  DOI：

  10.1016/0223-5234(96)88251-1

文献信息

• [EN] BROAD SPECTRUM ANTIVIRAL COMPOUNDS TARGETING THE SKI COMPLEX<br/>[FR] COMPOSÉS ANTIVIRAUX À LARGE SPECTRE CIBLANT LE COMPLEXE SKI
  申请人：UNIV MARYLAND

  公开号：WO2020247860A1

  公开（公告）日：2020-12-10

  Compounds and methods of using the same for treating conditions alleviated by SKI complex inhibition, viral replication inhibition, or interferon signaling inducement are provided.
• Synthesis and dopaminergic activity of heterocyclic analogues of 5,6-dihydroxy-2-aminotetralins
  作者：Joan Bosch、Tomàs Roca、Carles G. Pérez、Stefania Montanari

  DOI：10.1016/s0960-894x(00)00049-4

  日期：2000.3

  of 5,6-dihydroxy-2-aminotetralins (6) were synthesized and their in vitro dopaminergic activity was compared to that of (-)-DP-5,6-ADTN and the novel potent agonist Z12571. The results show that changing the cathecol ring for a heterocycle decreases the D1-like activity of the target molecules 6. However, the D2-like activity of tetrahydroquinoline (6j) was comparable to that of (-)-DP-5,6-ADTN.

  合成了5,6-二羟基-2-氨基四氢萘的杂环类似物（6），并将其体外多巴胺能活性与（-）-DP-5,6-ADTN和新型强效激动剂Z12571进行了比较。结果表明，改变杂环的导管环会降低目标分子6的D1样活性。但是，四氢喹啉（6j）的D2样活性与（-）-DP-5,6-相当。 ADTN。
• New 2-pyridylethylamines with dopaminergic activity: Synthesis and radioligand-binding evaluation
  作者：F Claudi、GM Cingolani、G Giorgioni、M Cardellini、F Amenta、C Polidori

  DOI：10.1016/0223-5234(96)88251-1

  日期：1995.1

  In order to determine whether the pyridine nucleus could replace the catechol moiety of the neurotransmitter dopamine or the phenol ring of the dopaminergic pharmacophore m-hydroxyphenylethylamine, the 2-(3-pyridyl)ethylamine 7, 2-(4-pyridyl)ethylamine 8, 2-(2-hydroxy-4-pyridyl) ethylamine 10 and their N,N-di-n-propyl- and N-n-propyl-N-2-phenylethyl derivatives were synthesized. The affinities of the new compounds for D-1 and D-2 dopamine receptors were evaluated by displacement of [H-3]SCH 23390 (D-1 selective) and [H-3]spiperone (D-2 selective) on rat neostriatum sections. The 2-(4-pyridyl)ethylamine 8 and its N,N-di-n-propyl derivative 18 showed the same affinity for the D-1 and D-2 receptors. Other compounds bound to the D-1 receptor with higher affinity than to the D-2 receptor. The possibility that the above compounds act as agonists and antagonists at the dopamine D-1 and D-2 receptors is discussed on the basis of guanosine-5'-triphosphate and Na+ displacement curves.