(E)-5-[1’-hydroxyimino-1’-(p-bromophenyl)methyl]dipyrromethane | 1628779-61-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-5-[1’-hydroxyimino-1’-(p-bromophenyl)methyl]dipyrromethane
• 英文别名: (NE)-N-[1-(4-bromophenyl)-2,2-bis(1H-pyrrol-2-yl)ethylidene]hydroxylamine
• CAS: 1628779-61-2
• 化学式: C₁₆H₁₄BrN₃O
• 分子量: 344.211
• InChiKey: LBAODSADEQINGR-SILNSSARSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  64.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吡咯 、 2,2-dibromo-1-(4’-bromophenyl)ethanone oxime 在 sodium carbonate 作用下， 以 水 为溶剂， 反应 4.0h， 以44%的产率得到
  参考文献：
  名称：

  On-Water Synthesis of Dipyrromethanes via Bis-Hetero-Diels–Alder Reaction of Azo- and Nitrosoalkenes with Pyrrole

  摘要：

  An unprecedented one-pot approach to 5-substituted dipyrromethanes based on the hetero-Diels-Alder reaction of azo- and nitrosoalkenes is described. The on-water reaction conditions led to the target compounds in higher yields with significantly shorter reaction times and simpler purification procedures than carrying out the reaction in dichloromethane or in the absence of solvent.

  DOI：

  10.1055/s-0033-1340300

文献信息

• On-Water Synthesis of Dipyrromethanes via Bis-Hetero-Diels–Alder Reaction of Azo- and Nitrosoalkenes with Pyrrole
  作者：Américo Lemos、Teresa Pinho e Melo、Nelson Pereira、Susana Lopes

  DOI：10.1055/s-0033-1340300

  日期：——

  An unprecedented one-pot approach to 5-substituted dipyrromethanes based on the hetero-Diels-Alder reaction of azo- and nitrosoalkenes is described. The on-water reaction conditions led to the target compounds in higher yields with significantly shorter reaction times and simpler purification procedures than carrying out the reaction in dichloromethane or in the absence of solvent.