2-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanol | 480453-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanol
• 英文别名: (S)-2-(2-(Hydroxymethyl)pyrrolidin-1-yl)ethanol；2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethanol
• CAS: 480453-62-1
• 化学式: C₇H₁₅NO₂
• 分子量: 145.202
• InChiKey: HKFUMQBPCRRDAV-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanol 在 镍 二乙胺 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 生成 [(2S)-1-(2-diphenylphosphanylethyl)pyrrolidin-2-yl]methyl-diphenylphosphane
  参考文献：
  名称：

  Examining the effect of hemilabile donor groups in non-C2 symmetrical terdentate ligands

  摘要：

  The type and position of donor atoms in proline-derived, non-C-2 symmetric, terdentate ligands are found to have significant effects on the enantioselectivity of the palladium-catalysed allylic substitution reaction. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00988-7
• 作为产物：
  描述：

  N-methoxycarbonylmethyl-L-proline methyl ester 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以98%的产率得到2-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-ethanol
  参考文献：
  名称：

  Examining the effect of hemilabile donor groups in non-C2 symmetrical terdentate ligands

  摘要：

  The type and position of donor atoms in proline-derived, non-C-2 symmetric, terdentate ligands are found to have significant effects on the enantioselectivity of the palladium-catalysed allylic substitution reaction. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00988-7

文献信息

• Chemical compounds
  申请人：Heron Murdoch Nicola

  公开号：US20060270692A1

  公开（公告）日：2006-11-30

  Quinazoline derivatives of formula (I); for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to process for their preparation, as well as pharmaceutical compositions containing them as active ingredient.

  公式(I)的喹唑啉衍生物；用于治疗增殖性疾病，例如癌症，并用于制备用于治疗增殖性疾病的药物，以及其制备过程，以及包含它们作为活性成分的制药组合物。
• Amide derivatives
  申请人：Brown Sutherland Dearg

  公开号：US20070043065A1

  公开（公告）日：2007-02-22

  The invention concerns a compound of the Formula (I) wherein m is 0-2 and each R 1 is a group such as hydroxy, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R 2 is halogeno, trifluoromethyl or (1-6C)alkyl; R 3 is hydrogen, halogeno or (1-6C)alkyl; and R 4 is (3-6C)cycloalkyl; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

  本发明涉及公式(I)的化合物，其中m为0-2，每个R1是羟基、卤素、三氟甲基、杂环基和杂环氧基等基团；R2为卤素、三氟甲基或(1-6C)烷基；R3为氢、卤素或(1-6C)烷基；R4为(3-6C)环烷基；或其药学上可接受的盐；制备它们的方法、含有它们的制药组合物以及它们在治疗由细胞因子介导的疾病或医疗情况中的应用。
• QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER
  申请人：AstraZeneca AB

  公开号：EP1613619B1

  公开（公告）日：2008-03-26
• US7691867B2
  申请人：——

  公开号：US7691867B2

  公开（公告）日：2010-04-06
• Examining the effect of hemilabile donor groups in non-C2 symmetrical terdentate ligands
  作者：Hubert Lam、Xiaohui Cheng、Jonathan W. Steed、David J. Aldous、King Kuok (Mimi) Hii

  DOI：10.1016/s0040-4039(02)00988-7

  日期：2002.8

  The type and position of donor atoms in proline-derived, non-C-2 symmetric, terdentate ligands are found to have significant effects on the enantioselectivity of the palladium-catalysed allylic substitution reaction. (C) 2002 Elsevier Science Ltd. All rights reserved.