bis-(2-chloro-ethyl)-[2]thienylmethyl-amine; hydrochloride | 14742-53-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis-(2-chloro-ethyl)-[2]thienylmethyl-amine; hydrochloride
• 英文别名: Bis-(2-chlor-aethyl)-[2]thienylmethyl-amin; Hydrochlorid；2-chloro-N-(2-chloroethyl)-N-(thiophen-2-ylmethyl)ethanamine;hydron;chloride
• CAS: 14742-53-1
• 化学式: C₉H₁₃Cl₂NS*ClH
• 分子量: 274.642
• InChiKey: JGMOSNLGCYXSCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.45
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  31.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 、 氯仿 作用下， 生成 bis-(2-chloro-ethyl)-[2]thienylmethyl-amine; hydrochloride
  参考文献：
  名称：

  Nitrogen Mustards

  摘要：

  DOI：

  10.1021/ja01152a023
• 作为试剂：
  描述：

  DCTA bromide 、 N,N-二甲基甲酰胺 、 、 三乙胺 、 溶剂黄146 在 氩 、 HS--CH2 -CH2 -SH 、 苯 、 溶剂黄146 、 bis-(2-chloro-ethyl)-[2]thienylmethyl-amine; hydrochloride 、 盐酸 作用下， 以 氧气 为溶剂， 反应 2.0h， 生成 bis-(2-chloro-ethyl)-[2]thienylmethyl-amine; hydrochloride
  参考文献：
  名称：

  Detectable molecules, method preparation and use

  摘要：

  一种可检测的分子，其化学式为A.sup.3 --(--X--R.sup.1 --E--Det.sup.b).sub.m，其中A.sup.3是A.sup.2或聚合物，A.sup.3具有至少一种可修饰的反应基团，所述反应基团选自氨基，羟基，顺式羟基，卤素，芳基，咪唑基，羰基，羧基，硫醇或包含活性碳的残基；--X--选自以下组合：##STR1## C.sub.1 -C.sub.10支链或直链烷基或芳基烷基，其可以被--OH取代；--Y--是直接键连接到--E--，或者--Y--是--E--R.sup.2 --，其中R.sup.2是C.sub.1 -C.sub.10支链或直链烷基；Z.sub.a是氯，溴或碘；E是O，NH或无环二价硫原子；Det.sup.b是一种能够被检测的化学基团，优选包括生物素或金属螯合剂，该金属螯合剂的化学式为：##STR2## 或其4-羟基或酰氧衍生物，其中R.sup.3是C.sub.1 -C.sub.4烷基或CH.sub.2 COOM，M相同或不同，选自氢，金属或非金属阳离子或C.sub.1 -C.sub.10烷基，芳基或芳基烷基；m是1到A.sup.3上修饰反应基团总数的整数。这些可检测的分子在体外或体内检测或治疗中非常有用。

  公开号：

  US05002885A1

文献信息

• Detectable molecules, method of preparation and use
  申请人：Enzo Biochem, Inc.

  公开号：US04943523A1

  公开（公告）日：1990-07-24

  A detectable molecule of the formula A.sup.3 --(--X--R.sup.1 --E--Det.sup.b).sub.m where A.sup.3 is A.sup.2 or a polymer, where A.sup.3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, thiol or a residue comprising an activated carbon; --X-- is selected from the group consisting of ##STR1## a C.sub.1 -C.sub.10 branched or unbranched alkyl or aralkyl, which may be substituted by --OH; --Y-- is a direct bond to --E--, or --Y-- is --E--R.sup.2 -- where R is a C.sub.1 -C.sub.10 branched or unbranched alkyl; Z.sub.a is chlorine, bromine or iodine; E is O, NH or an acyclic divalent sulfur atom; Det.sup.b is a chemical moiety capable of being detected, preferably comprising biotin or a metal chelator of the formula: ##STR2## or the 4-hydroxy or acyloxy derivative thereof, where R.sup.3 is C.sub.1 -C.sub.4 alkyl or CH.sub.2 COOM, M is the same or different and selected from the group consisting of hydrogen, a metal or non-metal cation or is C.sub.1 -C.sub.10 alkyl, aryl or aralkyl; and m is an integer from 1 to the total number of modified reactive groups on A.sup.3. The detectable molecules are useful in in vitro or in vivo assays or therapy.

  一种可检测的分子，其化学式为A.sup.3 --(--X--R.sup.1 --E--Det.sup.b).sub.m，其中A.sup.3为A.sup.2或聚合物，A.sup.3具有至少一种可修饰的反应性基团，所述反应性基团选自氨基、羟基、顺式羟基、卤素、芳基、咪唑基、羰基、羧基、巯基或包含活性碳的残基；--X--选自以下组中的一种：##STR1## C.sub.1-C.sub.10支链或非支链烷基或芳基烷基，可被--OH取代；--Y--是直接键连接到--E--，或--Y--是--E--R.sup.2--，其中R是C.sub.1-C.sub.10支链或非支链烷基；Z.sub.a为氯、溴或碘；E为O、NH或非环二价硫原子；Det.sup.b是可被检测的化学基团，优选包括生物素或配位金属螯合剂，其化学式为：##STR2## 或其4-羟基或酰氧衍生物，其中R.sup.3为C.sub.1-C.sub.4烷基或CH.sub.2COOM，M相同或不同，选自氢、金属或非金属阳离子，或C.sub.1-C.sub.10烷基、芳基或芳基烷基；m为1到A.sup.3上修饰反应性基团总数的整数。该可检测分子在体外或体内检测或治疗中有用。
• Compound and detectable molecules having an oligo- or polynucleotide
  申请人：Enzo Diagnostics, Inc.

  公开号：US05175269A1

  公开（公告）日：1992-12-29

  A detectable molecule of the formula A.sup.3 --(--X--R.sup.1 --E--Det.sup.b).sub.m where A.sup.3 is A.sup.2 or a polymer, where A.sup.3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, thiol or a residue comprising an activated carbon; --X-- is selected from the group consisting of ##STR1## or a C.sub.1 -C.sub.10 branched or unbranched alkyl or aralkyl, which may be substituted by --OH; --Y-- is a direct bond to --E--, or --Y-- is --E--R.sup.2 -- where R.sup.2 is a C.sub.1 -C.sub.10 branched or unbranched alkyl; Z.sub.a is chlorine, bromine or iodine; E is O, NH or an acyclic divalent sulfur atom; Det.sup.b is a chemical moiety capable of being detected, preferably comprising biotin or a metal chelator of the formula: ##STR2## or the 4-hydroxy or acyloxy derivative thereof, where R.sup.3 is C.sub.1 -C.sub.4 alkyl or CH.sub.2 COOM, M is the same or different and selected from the group consisting of hydrogen, a metal or non-metal cation or is C.sub.1 -C.sub.10 alkyl, aryl or aralkyl; and m is an integer from 1 to the total number of modified reactive groups on A.sup.3. The detectable molecules are useful in in vitro or in vivo assays or therapy.

  一种可检测的分子，其化学式为A.sup.3--(--X--R.sup.1--E--Det.sup.b).sub.m，其中A.sup.3为A.sup.2或聚合物，A.sup.3具有至少一个可修饰的反应基团，所述反应基团选自氨基、羟基、顺式羟基、卤化物、芳基、咪唑基、羰基、羧基、硫醇或包含活性碳的残基；--X--选自以下组合之一：##STR1## 或C.sub.1-C.sub.10支链或非支链烷基或芳基烷基，其可以被--OH取代；--Y--是直接键连接到--E--，或--Y--是--E--R.sup.2--，其中R.sup.2是C.sub.1-C.sub.10支链或非支链烷基；Z.sub.a是氯、溴或碘；E是O、NH或无环二价硫原子；Det.sup.b是一种可检测的化学基团，优选包括生物素或公式为：##STR2## 或其4-羟基或酰氧衍生物，其中R.sup.3为C.sub.1-C.sub.4烷基或CH.sub.2COOM，M相同或不同，选自氢、金属或非金属阳离子或C.sub.1-C.sub.10烷基、芳基或芳基烷基；m是从1到A.sup.3上修饰反应基团总数的整数。这些可检测的分子在体外或体内检测或治疗中非常有用。
• Nucleic acid hybridization assay and detectable molecules useful in such
  申请人：Enzo Biochem, Inc.

  公开号：US04707440A1

  公开（公告）日：1987-11-17

  A detectable molecule of the formula A.sup.3 --(--X--R.sup.1 --E--Det.sup.b).sub.m where A.sup.3 is A.sup.2 or a polymer, where A.sup.3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, thiol or a residue comprising an activated carbon; --X-- is selected from the group consisting of ##STR1## --R.sup.1 -- is ##STR2## or a C.sub.1 -C.sub.10 branched or unbranched alkyl or aralkyl, which may be substituted by --OH; --Y-- is a direct bond to --E--, or --Y-- is --E--R.sup.2 -- where R.sup.2 is a C.sub.1 -C.sub.10 branched or unbranched alkyl; Z.sub.a is chlorine, bromine or iodine; E is O, NH or an acyclic divalent sulfur atom; Det.sup.b is a chemical moiety capable of being detected, preferably comprising biotin or a metal chelator of the formula: ##STR3## or the 4-hydroxy or acyloxy derivative thereof, where R.sup.3 is C.sub.1 -C.sub.4 alkyl or CH.sub.2 COOM, M is the same or different and selected from the group consisting of hydrogen, a metal or non-metal cation or is C.sub.1 -C.sub.10 alkyl, aryl or aralkyl; and m is an integer from 1 to the total number of modified reactive groups on A.sup.3. The detectable molecules are useful in in virto or in vivo assays or therapy.

  具有以下分子式的可检测分子：A.sup.3 --(--X--R.sup.1 --E--Det.sup.b).sub.m，其中A.sup.3是A.sup.2或聚合物，A.sup.3具有至少一种可修饰反应基团，所述反应基团选自氨基，羟基，顺式OH，卤素，芳基，咪唑基，羰基，羧基，硫醇或包含活性碳的残基；--X--选自以下组成的群：##STR1## --R.sup.1 --是##STR2##或C.sub.1-C.sub.10支链或直链烷基或芳基烷基，可以被--OH取代；--Y--是直接连接到--E--的键或--Y--是--E--R.sup.2 --，其中R.sup.2是C.sub.1-C.sub.10支链或直链烷基；Z.sub.a是氯，溴或碘；E是O，NH或无环二价硫原子；Det.sup.b是可检测的化学基团，优选包括生物素或公式为：##STR3##或其4-羟基或酰氧衍生物，其中R.sup.3是C.sub.1-C.sub.4烷基或CH.sub.2 COOM，M相同或不同，选自氢，金属或非金属阳离子或C.sub.1-C.sub.10烷基，芳基或芳基烷基；m是1到A.sup.3上修饰反应基团总数的整数。该可检测分子在体外或体内测定或治疗中有用。
• ASSAY METHOD UTILIZING POLYNUCLEOTIDE SEQUENCES
  申请人：PERGOLIZZI ROBERT

  公开号：US20100273145A1

  公开（公告）日：2010-10-28

  A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex.

  一种检测样品中具有分子可识别部分的分析物（A）的方法，其包括：提供（B）具有以下内容的分子桥接实体：（i）能够识别分析物上的分子可识别部分的部分；和（ii）包含多核苷酸序列的部分；以及（C）具有以下内容的信号实体：（i）能够与桥接实体的多核苷酸部分互相结合，从而形成稳定的多核苷酸杂交体的多核苷酸部分；和（ii）信号生成部分；形成复合物，其中包括：（1）经其分子可识别部分与（2）实体（B）的识别部分络合的分析物（A）；实体（B）通过其上的多核苷酸部分与（3）信号实体的多核苷酸部分络合；并通过在复合物中存在的信号生成部分检测信号。
• Analyte detection utilizing polynucleotide sequences, composition, process and kit
  申请人：Pergolizzi Robert G.

  公开号：US09134302B2

  公开（公告）日：2015-09-15

  A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex.

  一种检测样品中具有分子可识别部分的分析物（A）的方法，包括：提供（B）一种具有以下部分的分子桥接实体：（i）能够识别分析物上的分子可识别部分的部分；和（ii）包括一个多核苷酸序列的部分；和（C）一种信号实体，其上具有：（i）能够与桥接实体的多核苷酸部分退火形成稳定的多核苷酸杂交的多核苷酸部分，和（ii）信号产生部分；形成复合物，包括：（1）分析物（A）通过其分子可识别部分与（2）实体（B）的识别部分络合；实体（B）通过其上的多核苷酸部分与（3）信号实体的多核苷酸部分络合；并通过存在于复合物中的信号产生部分检测信号。