N-烯丙基-4-氨基苯磺酰胺 | 117057-51-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-烯丙基-4-氨基苯磺酰胺
• 中文别名: 4-氨基-N-丙-2-烯基苯磺酰胺
• 英文名称: N-Allyl-4-aminobenzenesulfonamide
• 英文别名: sulfanilic acid allylamide；Sulfanilsaeure-allylamid；4-amino-N-prop-2-enylbenzenesulfonamide
• CAS: 117057-51-9
• 化学式: C₉H₁₂N₂O₂S
• mdl: MFCD05666703
• 分子量: 212.272
• InChiKey: ZAYPEKUIXUZNDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  4-phenylbenzoyl isothiocyanate 、 N-烯丙基-4-氨基苯磺酰胺 以 丙酮 为溶剂， 以0.13 g的产率得到N-((4-(N-allylsulfamoyl)phenyl)carbamothioyl)-[1,1'-biphenyl]-4-carboxamide
  参考文献：
  名称：

  Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

  摘要：

  To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HIS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of nanomolar potency GPR55 agonists with N-(4-sulfamoylphenyl)thiourea scaffold. The GPR55 activity of the compounds were screened by using a commercial beta-arrestin PathHunter assay and the potential compounds were further evaluated by using a recombinant HEK cell line exhibiting GPR55-mediated effects on calcium signalling. The designed compounds were not active when tested against various endocannabinoid targets (CB1R, CB2R, FAAH, MGL, ABHD6 and ABHD12), indicating compounds' selectivity for the GPR55. Finally, structure activity relationships of these compounds were explored. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.10.050
• 作为产物：
  描述：

  N-allyl-p-nitrobenzenesulfonamide 在 盐酸 、 tin 作用下， 以 乙醇 、 水 为溶剂， 以100%的产率得到N-烯丙基-4-氨基苯磺酰胺
  参考文献：
  名称：

  Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

  摘要：

  To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HIS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of nanomolar potency GPR55 agonists with N-(4-sulfamoylphenyl)thiourea scaffold. The GPR55 activity of the compounds were screened by using a commercial beta-arrestin PathHunter assay and the potential compounds were further evaluated by using a recombinant HEK cell line exhibiting GPR55-mediated effects on calcium signalling. The designed compounds were not active when tested against various endocannabinoid targets (CB1R, CB2R, FAAH, MGL, ABHD6 and ABHD12), indicating compounds' selectivity for the GPR55. Finally, structure activity relationships of these compounds were explored. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.10.050

文献信息

• COLORING COMPOSITION, CURED FILM, COLOR FILTER, METHOD FOR PRODUCING COLOR FILTER, SOLID-STATE IMAGING ELEMENT, IMAGE DISPLAY DEVICE, ORGANIC ELECTROLUMINESCENT ELEMENT, DYE AND METHOD FOR PRODUCING DYE
  申请人：Fujifilm Corporation

  公开号：EP3133126A1

  公开（公告）日：2017-02-22

  A coloring composition having excellent light fastness, color migration properties, and flatness, a colorant, and a method for producing a colorant are provided. Further, a cured film, a color filter, a method for manufacturing a color filter, a solid-state imaging device, an image display device, and an organic electroluminescent element, each using such the coloring composition, are also provided. The coloring composition contains a colorant represented by General Formula (1) and a curable compound, and has a specific absorbance of 5 or more at a maximum absorption wavelength of 400 nm to 800 nm. R1 represents an (m + n)-valent linking group, P represents a monovalent substituent having a repeating units derived from a vinyl compound, D represents a colorant structure, and R2 and L1 each independently represent a single bond or a divalent linking group.         (D-R2)nR1-(L1-P)m     (1)

  本发明提供了一种具有优异耐光性、色彩迁移特性和平整度的着色组合物、着色剂以及生产着色剂的方法。此外，还提供了一种固化薄膜、一种彩色滤光片、一种制造彩色滤光片的方法、一种固态成像装置、一种图像显示装置和一种有机电致发光元件，它们都使用了这种着色组合物。着色组合物含有通式（1）表示的着色剂和可固化化合物，在最大吸收波长 400 纳米至 800 纳米处的比吸收率为 5 或更高。R1 代表(m+n)价连接基团，P 代表具有来自乙烯基化合物的重复单元的单价取代基，D 代表着色剂结构，R2 和 L1 各自独立地代表单键或二价连接基团。 (D-R2)nR1-(L1-P)m (1)
• Mangini, Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1940, vol. 1, p. 143
  作者：Mangini

  DOI：——

  日期：——
• Mangini, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1940, vol. <7> 1, p. 554,556
  作者：Mangini

  DOI：——

  日期：——
• PYRIMIDINE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1303496B1

  公开（公告）日：2007-09-12
• US4187225A
  申请人：——

  公开号：US4187225A

  公开（公告）日：1980-02-05