Dynamic Kinetic Resolution of 2-Phenylpropanal Derivatives to Yield β-Chiral Primary Amines<i>via</i>Bioamination
作者:Christine S. Fuchs、Manuel Hollauf、Maximilian Meissner、Robert C. Simon、Tatiana Besset、Joost N. H. Reek、Waander Riethorst、Ferdinand Zepeck、Wolfgang Kroutil
DOI:10.1002/adsc.201400217
日期:2014.7.7
The amination of racemic α‐chiral aldehydes, 2‐phenylpropanal derivatives, was investigated employing ω‐transaminases. By medium and substrate engineering the optical purity of the resulting β‐chiral chiral amine could be enhanced to reach optical purities up to 99% ee. Using enantiocomplementary ω‐transaminases allowed us to access the (R)‐ as well as the (S)‐enantiomer in most cases. It is important