N-环己-N-乙基乙酰胺 | 1128-34-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-环己-N-乙基乙酰胺
• 英文名称: N-cyclohexyl-N-ethylacetamide
• 英文别名: N-ethyl-N-cyclohexyl-acetamide；N-Aethyl-N-cyclohexyl-acetamid；Acetyl-aethyl-cyclohexyl-amin；N-Aethyl-acetamido-cyclohexan；N-Cyclohexyl-N-ethyl-acetamid
• CAS: 1128-34-3
• 化学式: C₁₀H₁₉NO
• mdl: MFCD18431886
• 分子量: 169.267
• InChiKey: QOFZICTWQWJEKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2924299090

反应信息

• 作为产物：
  描述：

  4-acetyl-1-thia-4-aza-spiro[4.5]decane 在 镍 作用下， 以 苯 为溶剂， 生成 N-环己-N-乙基乙酰胺
  参考文献：
  名称：

  1164.有机硫化合物的研究。第十七部分。通过噻唑烷类脱硫合成以前无法获得的酰化烯胺

  摘要：

  DOI：

  10.1039/jr9650006253

文献信息

• Catalytic N-Alkylation of Amines Using Carboxylic Acids and Molecular Hydrogen
  作者：Iván Sorribes、Jose R. Cabrero-Antonino、Cristian Vicent、Kathrin Junge、Matthias Beller

  DOI：10.1021/jacs.5b07994

  日期：2015.10.28

  green N-alkylation of amines has been accomplished by applying readily available carboxylic acids in the presence of molecular hydrogen. Applying an in situ formed ruthenium/triphos complex and an organic acid as cocatalyst, a broad range of alkylated secondary and tertiary amines are obtained in good to excellent yields. This novel method is also successfully applied for the synthesis of unsymmetrically

  通过在分子氢存在下应用容易获得的羧酸，已经实现了胺的方便、实用和绿色的 N-烷基化。应用原位形成的钌/三磷配合物和有机酸作为助催化剂，可以以良好到极好的收率获得范围广泛的烷基化仲胺和叔胺。这种新方法还成功地应用于通过相应胺、羧酸和作为 C1 源的 CO2 的直接三组分偶联反应合成不对称取代的 N-甲基/烷基苯胺。
• Novel benzylamine derivatives as CETP inhibitors
  申请人：Baruah Anima

  公开号：US20060178514A1

  公开（公告）日：2006-08-10

  The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

  本发明提供了包括新的苄胺化合物、含有苄胺化合物的组合物、制备苄胺化合物的方法以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的多种疾病或症状的方法等。
• Benzimidazole and Pyridylimidazole Derivatives
  申请人：Li Guiying

  公开号：US20080227793A1

  公开（公告）日：2008-09-18

  This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABA A receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABA A receptors in tissue sections.

  本发明涉及苯并咪唑、吡啶咪唑和相关的双环杂芳烃化合物，所有这些化合物都可以用公式I描述。本发明特别涉及与GABAA受体的苯二氮卓位点具有高选择性和高亲和力的这种化合物。本发明还涉及包含这种化合物的制药组合物以及在治疗某些中枢神经系统（CNS）疾病中使用这种化合物的用途。还公开了制备公式I化合物的新方法。本发明还涉及将公式I的苯并咪唑、吡啶咪唑和相关的双环杂芳烃化合物与一个或多个其他CNS药剂联合使用以增强其他CNS药剂的效果。此外，本发明还涉及将这些化合物用作定位组织切片中的GABAA受体的探针。
• Novel benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors
  申请人：Baruah Anima

  公开号：US20070015758A1

  公开（公告）日：2007-01-18

  The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

  本发明提供了新的苄基胺化合物，包括苄基胺化合物的组合物，制备苄基胺化合物的方法，以及使用苄基胺化合物治疗或预防与脂蛋白代谢有关的各种疾病或症状的方法。
• PYRAZOLE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS
  申请人：Chen L. Yuhpyng

  公开号：US20070270474A1

  公开（公告）日：2007-11-22

  The invention provides compounds of Formula I: wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 and A are as defined. Compounds of formula I have activity inhibiting production of Aβ-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.

  该发明提供了I式化合物：其中R1、R2、R3、R4、R6、R7、R8和A的定义如下。 I式化合物具有抑制Aβ肽的产生活性。该发明还提供了包含I式化合物的药物组合物和治疗哺乳动物疾病的方法，例如阿尔茨海默病。