5-chlorobiphenyl-2-carboxamide | 102871-45-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-chlorobiphenyl-2-carboxamide
• 英文别名: 4-Chloro-2-phenylbenzamide
• CAS: 102871-45-4
• 化学式: C₁₃H₁₀ClNO
• 分子量: 231.681
• InChiKey: CJIWKCXKZSOTBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  碘苯 、 4-氯苯甲酰胺 在 palladium diacetate 、 silver(l) oxide 作用下， 以 溶剂黄146 为溶剂， 反应 24.0h， 以38%的产率得到5-chlorobiphenyl-2-carboxamide
  参考文献：
  名称：

  Palladium-Catalyzed Ortho-Arylation of Benzamides via Direct sp²C–H Bond Activation

  摘要：

  The palladium-catalyzed ortho-arylation of benzamides by aryl iodides has been demonstrated with the simplest amide CONH2 as a directing group for the first time. This protocol can be applied to various benzamides and aryl iodides with both electron-donating and electron-withdrawing groups. In addition, the synthesized biphenyl-2-carboxamides can be further transformed to other biphenyl derivatives such as nitriles, carboxylic acids, carbamates, and amines.

  DOI：

  10.1021/jo300126n

文献信息

• [EN] NEW AGENTS FOR TREATING NEUROGENIC INFLAMMATION AND NEUROPATHIC HYPERALGESIA RELATED DISORDERS<br/>[FR] NOUVEAUX AGENTS DESTINÉS À TRAITER L'INFLAMMATION NEUROGÈNE ET LES TROUBLES ASSOCIÉS À L'HYPERALGÉSIE
  申请人：PÉCSI TUDOMÁNYEGYETEM

  公开号：WO2016042349A1

  公开（公告）日：2016-03-24

  The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. Said 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine compounds have been identified as new drug candidates for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia.

  本发明涉及4-苯乙氨基-7H-吡咯并[2,3-d]嘧啶衍生物及其溶剂化物、水合物和药学上可接受的盐，以及其制造过程，它们的用途，以及含有至少其中一种作为药学活性成分的药物组合物，连同药学上可接受的载体、赋形剂和/或稀释剂，特别用于预防和/或治疗急性神经源性炎症和/或神经病性过敏。所述的4-苯乙氨基-7H-吡咯并[2,3-d]嘧啶化合物已被确认为预防和/或治疗急性神经源性炎症和/或神经病性过敏的新药物候选物。
• Agents for treating neurogenic inflammation and neuropathic hyperalgesia related disorders
  申请人：PÉCSI TUDOMÁNYEGYETEM

  公开号：US10344032B2

  公开（公告）日：2019-07-09

  The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. Said 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine compounds have been identified as new drug candidates for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia.

  本发明涉及4-苯乙酰胺基-7H-吡咯并[2,3-d]嘧啶衍生物及其溶解物、水合物和药学上可接受的盐、它们的制造工艺、它们的用途，以及含有至少一种它们作为药学活性剂的药物组合物和药学上可接受的载体、赋形剂和/或稀释剂，特别是用于预防和/或治疗急性神经源性炎症和/或神经病理性痛觉减退。所述 4-苯乙胺基-7H-吡咯并[2,3-d]嘧啶化合物已被确定为预防和/或治疗急性神经源性炎症和/或神经病理性痛觉减退的候选新药。
• NEW AGENTS FOR TREATING NEUROGENIC INFLAMMATION AND NEUROPATHIC HYPERALGESIA RELATED DISORDERS
  申请人：Pécsi Tudományegyetem

  公开号：EP3194399A1

  公开（公告）日：2017-07-26
• Palladium-Catalyzed Ortho-Arylation of Benzamides via Direct sp²C–H Bond Activation
  作者：Dan-Dan Li、Ting-Ting Yuan、Guan-Wu Wang

  DOI：10.1021/jo300126n

  日期：2012.4.6

  The palladium-catalyzed ortho-arylation of benzamides by aryl iodides has been demonstrated with the simplest amide CONH2 as a directing group for the first time. This protocol can be applied to various benzamides and aryl iodides with both electron-donating and electron-withdrawing groups. In addition, the synthesized biphenyl-2-carboxamides can be further transformed to other biphenyl derivatives such as nitriles, carboxylic acids, carbamates, and amines.