2-[[(E)-octadec-9-enoyl]amino]ethanesulfonic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[[(E)-octadec-9-enoyl]amino]ethanesulfonic acid
• 化学式: C₂₀H₃₉NO₄S
• 分子量: 389.6
• InChiKey: KOGRJTUIKPMZEJ-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  26
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CONJUGATES OF POLYUNSATURATED FATTY ACIDS AND AMINE-CONTAINING COMPOUNDS AND USES THEREOF
  申请人：MedWell Laboratories Ltd.

  公开号：US20160120995A1

  公开（公告）日：2016-05-05

  Novel chemical conjugates derived from unsaturated fatty acids and therapeutically active agents, are disclosed. The chemical conjugates are designed and characterized as COX-2 and/or 5-LOX inhibitors and are useful in the treatment of inflammatory diseases, dermatitis and disorders such as Alzheimer's disease, Parkinson's disease, asthma, osteoarthritis, rheumatoid arthritis, pain, primary dysmenorrhea, Crohn's disease and ulcerative colitis.

  本发明揭示了从不饱和脂肪酸和治疗活性剂衍生的新型化学共轭物。这些化学共轭物被设计和表征为COX-2和/或5-LOX抑制剂，并可用于治疗炎症性疾病、皮炎和阿尔茨海默病、帕金森病、哮喘、骨关节炎、类风湿性关节炎、疼痛、原发性痛经、克罗恩病和溃疡性结肠炎等疾病。
• [EN] CONJUGATES OF POLYUNSATURATED FATTY ACIDS AND AMINE-CONTAINING COMPOUNDS AND USES THEREOF<br/>[FR] CONJUGUÉS D'ACIDES GRAS POLYINSATURÉS ET DE COMPOSÉS CONTENANT DES AMINES ET LEURS UTILISATIONS
  申请人：MEDWELL LAB LTD

  公开号：WO2012032509A2

  公开（公告）日：2012-03-15

  Novel chemical conjugates derived from unsaturated fatty acids and therapeutically active agents, are disclosed. The chemical conjugates are designed and characterized as COX-2 and/or 5-LOX inhibitors and are useful in the treatment of inflammatory diseases and disorders such as Alzheimer's disease, Parkinson's disease, asthma, osteoarthritis, rheumatoid arthritis, pain, primary dysmenorrhea, Crohn's disease and ulcerative colitis.