1-(2-Aethyl-2-methyl-hexanoyl)-morpholin | 13146-43-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1-(2-Aethyl-2-methyl-hexanoyl)-morpholin
• 英文别名: 4-(2-ethyl-2-methyl-hexanoyl)-morpholine；4-(2-Ethyl-2-methylhexanoyl)morpholine；2-ethyl-2-methyl-1-morpholin-4-ylhexan-1-one
• CAS: 13146-43-5
• 化学式: C₁₃H₂₅NO₂
• 分子量: 227.347
• InChiKey: AXZANOURTPQIGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Neprilysin inhibitors
  申请人：THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：US10336773B2

  公开（公告）日：2019-07-02

  In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

  一方面，本发明涉及具有以下式子的化合物： 其中 R1-R6、a、b 和 X 如说明书中所定义，或其药学上可接受的盐。这些化合物具有肾酶抑制活性。在另一方面，本发明涉及包含此类化合物的药物组合物；使用此类化合物的方法；以及制备此类化合物的工艺和中间体。
• NEPRILYSIN INHIBITORS
  申请人：THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：US20170022219A1

  公开（公告）日：2017-01-26

  In one aspect, the invention relates to compounds having the formula: where R 1 -R 6 , a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
• US9688692B2
  申请人：——

  公开号：US9688692B2

  公开（公告）日：2017-06-27
• US9873696B2
  申请人：——

  公开号：US9873696B2

  公开（公告）日：2018-01-23