喜树碱
相关化合物
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | (19S)-19-hydroxy-10-methoxy-19-(2-morpholin-4-yl-2-oxoethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C25H23N3O7 |
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| —— | Camptothecinethylglycinate esterhydrochloride | —— | C24H24ClN3O5 |
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| —— | Camptothecin,20-O-((4-(2-hydroxyethyl)-1-piperazino)oac | —— | C28H30N4O6 |
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| —— | N'-[[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylideneamino]oxamide;hydrochloride | —— | C23H20ClN5O6 |
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| —— | N-[[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylideneamino]pyrrolidine-2-carboxamide;hydrochloride | —— | C26H26ClN5O5 |
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| —— | 2-amino-N-[[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methylideneamino]-4-methylpentanamide;hydrochloride | —— | C27H30ClN5O5 |
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| —— | (19-Ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl) 2,6-diaminohexanoate;hydrochloride | —— | C26H29ClN4O5 |
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| —— | 19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),4,7,9,15(20)-hexaene-6,14,18-trione | —— | C20H16N2O6 |
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| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-3-methylpentanamide | —— | C27H29N5O5 |
|
| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-3-(4-hydroxyphenyl)propanamide | —— | C30H27N5O6 |
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| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-4-methylpentanamide | —— | C27H29N5O5 |
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| —— | [(19R)-8-amino-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-(dimethylamino)acetate | —— | C24H24N4O5 |
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| —— | [(19R)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-(dimethylamino)acetate | —— | C24H23N3O5 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[[2-[2-[2-[[4-[[4-[3,5-bis[[bis(pyridin-2-ylmethyl)amino]methyl]phenoxy]butyl-[1-(4-chlorophenyl)cyclohexanecarbonyl]amino]methyl]benzoyl]amino]ethoxy]ethoxy]ethyl-[1-(4-chlorophenyl)cyclohexanecarbonyl]amino]methyl]benzoate | —— | C106H111Cl2N11O12 |
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| —— | 7,19-Dihydroxy-19-propyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione | —— | C21H18N2O5 |
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| —— | 4-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]benzamide | —— | C28H23N5O5 |
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| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]propanamide | —— | C24H23N5O5 |
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| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-3-(1H-imidazol-5-yl)propanamide | —— | C27H25N7O5 |
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| —— | N-[(E)-(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-2-pyridin-1-ium-1-ylacetamide | —— | C28H24N5O5+ |
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| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-4-methylsulfanylbutanamide | —— | C26H27N5O5S |
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| —— | 5-[[1-[(10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl)oxycarbonyl]piperidin-4-yl]amino]pentanoic acid;hydrochloride | —— | C33H39ClN4O8 |
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| —— | Methyl 3,4,5-triacetyloxy-6-[(10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl)oxy]oxane-2-carboxylate | —— | C35H36N2O14 |
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| —— | SN-38 glucuronide-13C6 | —— | C28H28N2O11 |
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| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-3-sulfanylpropanamide | —— | C24H23N5O5S |
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| —— | (20S)-disodium 2-hydroxy-2-(3-hydroxymethyl-9-olato-4-oxo-4,6-dihydroindolizino[1,2-b]quinolin-2-yl)butanoate | —— | C20H16N2O6-2 |
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| —— | (20RS)-Sodium; 2-(1-amino-8-hydroxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-b]quinolin-7-yl)-2-hydroxy-butyrate | —— | C20H18N3O5- |
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| —— | (20R)-sodium 2-(13-amino-8-hydroxymethyl-9-oxo-9,11-dihydro[1,3]dioxolo[5,4-g]indolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoate | —— | C21H18N3O7- |
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| —— | (20RS)-sodium 2-hydroxy-2-(8-hydroxymethyl-9-oxo-9,11-dihydro[1,3]dioxolo[5,4-g]indolizino[1,2-b]quinolin-7-yl)butanoate | —— | C21H17N2O7- |
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| —— | (2S)-2-hydroxy-2-[7-(hydroxymethyl)-8-oxo-16,18-dioxa-2,9-diazapentacyclo[11.7.0.03,11.04,9.015,19]icosa-1,3(11),4,6,12,14,19-heptaen-6-yl]butanoate | —— | C21H17N2O7- |
|
| —— | (2S)-2-[14-amino-7-(hydroxymethyl)-8-oxo-16,18-dioxa-2,9-diazapentacyclo[11.7.0.03,11.04,9.015,19]icosa-1(20),2,4,6,11,13,15(19)-heptaen-6-yl]-2-hydroxybutanoate | —— | C21H18N3O7- |
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| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-3-hydroxypropanamide | —— | C24H23N5O6 |
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| —— | (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;(5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one | —— | C42H40N6O8 |
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| —— | sodium;[(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphite | —— | C20H16N2NaO6P |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoate | —— | C36H37Cl2N3O6 |
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| —— | [2-[(2Z)-2-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylidene]hydrazinyl]-2-oxoethyl]-trimethylazanium | —— | C26H28N5O5+ |
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| —— | (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione;octadecan-1-amine | —— | C38H55N3O4 |
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| —— | Oratecan | —— | C33H38N4O6*(x)ClH |
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| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]acetamide | —— | C23H21N5O5 |
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| —— | ethane;(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C26H34N2O4 |
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| —— | [(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-[methyl(propanoyl)amino]acetate;[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-(propanoylamino)acetate;[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] (2S)-2-(propanoylamino)propanoate;[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),3,5,7,9,15(20)-hexaen-19-yl] 4-methylsulfanyl-2-(propanoylamino)butanoate | —— | C113H120N12O28S |
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| —— | [19-(2-Aminoacetyl)oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;deuterioethyne;1-ethoxy-2-methoxyethane | —— | C42H55N5O9 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 11-[3-[bis(phosphanyl)methylsulfanyl]-2,5-dihydroxypyrrol-1-yl]undecanoate | —— | C38H47N3O8P2S |
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| —— | (19S)-19-ethyl-19-hydroxy-10-(3-piperidin-3-ylprop-1-ynyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C28H27N3O4 |
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| —— | (10,19-Diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) [3-methyl-2-[[6-(methylamino)-2-[[2-(2-oxopropoxy)acetyl]amino]hexanoyl]amino]butyl] carbonate | —— | C40H51N5O11 |
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| —— | O-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]] N-octadeca-9,12-dienylcarbamothioate | —— | C41H53N3O5S |
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| —— | (19S)-19-ethyl-19-hydroxy-7-(morpholin-4-ylmethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione | —— | C25H25N3O5 |
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| —— | (10,19-Diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) [2-[[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethylamino]-2-oxoethoxy]acetyl]amino]-3-methylbutyl] carbonate;[19-[2-[[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethylamino]-2-oxoethoxy]acetyl]amino]-3-methylbutoxy]carbonyloxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy-methylborinic acid | —— | C103H125BN18O29 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] N-octadeca-9,12-dienylcarbamate | —— | C41H53N3O6 |
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| —— | 18-Ethyl-18-methoxy-2-[2-(1-methylazepan-4-yl)ethyl]-6,9,20-trioxa-13,24-diazahexacyclo[12.11.0.03,12.05,10.015,24.017,22]pentacosa-1,3,5(10),11,13,15,17(22)-heptaene-19,23-dione | —— | C32H37N3O6 |
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| —— | ethyl 3-[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl]propanoate | —— | C25H24N2O6 |
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