喜树碱
相关化合物
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | (2S)-2-[14-amino-7-(hydroxymethyl)-8-oxo-16,18-dioxa-2,9-diazapentacyclo[11.7.0.03,11.04,9.015,19]icosa-1(20),2,4,6,11,13,15(19)-heptaen-6-yl]-2-hydroxybutanoate | —— | C21H18N3O7- |
| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]-3-hydroxypropanamide | —— | C24H23N5O6 |
| —— | (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;(5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one | —— | C42H40N6O8 |
| —— | sodium;[(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphite | —— | C20H16N2NaO6P |
| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoate | —— | C36H37Cl2N3O6 |
| —— | [2-[(2Z)-2-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylidene]hydrazinyl]-2-oxoethyl]-trimethylazanium | —— | C26H28N5O5+ |
| —— | (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione;octadecan-1-amine | —— | C38H55N3O4 |
| —— | Oratecan | —— | C33H38N4O6*(x)ClH |
| —— | 2-amino-N-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl)methylideneamino]acetamide | —— | C23H21N5O5 |
| —— | ethane;(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C26H34N2O4 |
| —— | [(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-[methyl(propanoyl)amino]acetate;[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-(propanoylamino)acetate;[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] (2S)-2-(propanoylamino)propanoate;[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),3,5,7,9,15(20)-hexaen-19-yl] 4-methylsulfanyl-2-(propanoylamino)butanoate | —— | C113H120N12O28S |
| —— | [19-(2-Aminoacetyl)oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;deuterioethyne;1-ethoxy-2-methoxyethane | —— | C42H55N5O9 |
| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 11-[3-[bis(phosphanyl)methylsulfanyl]-2,5-dihydroxypyrrol-1-yl]undecanoate | —— | C38H47N3O8P2S |
| —— | (19S)-19-ethyl-19-hydroxy-10-(3-piperidin-3-ylprop-1-ynyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C28H27N3O4 |
| —— | (10,19-Diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) [3-methyl-2-[[6-(methylamino)-2-[[2-(2-oxopropoxy)acetyl]amino]hexanoyl]amino]butyl] carbonate | —— | C40H51N5O11 |
| —— | O-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]] N-octadeca-9,12-dienylcarbamothioate | —— | C41H53N3O5S |
| —— | (19S)-19-ethyl-19-hydroxy-7-(morpholin-4-ylmethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione | —— | C25H25N3O5 |
| —— | (10,19-Diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) [2-[[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethylamino]-2-oxoethoxy]acetyl]amino]-3-methylbutyl] carbonate;[19-[2-[[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethylamino]-2-oxoethoxy]acetyl]amino]-3-methylbutoxy]carbonyloxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy-methylborinic acid | —— | C103H125BN18O29 |
| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] N-octadeca-9,12-dienylcarbamate | —— | C41H53N3O6 |
| —— | 18-Ethyl-18-methoxy-2-[2-(1-methylazepan-4-yl)ethyl]-6,9,20-trioxa-13,24-diazahexacyclo[12.11.0.03,12.05,10.015,24.017,22]pentacosa-1,3,5(10),11,13,15,17(22)-heptaene-19,23-dione | —— | C32H37N3O6 |
| —— | ethyl 3-[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl]propanoate | —— | C25H24N2O6 |
| —— | (19S)-19-ethyl-19-hydroxy-10-[(1-methylpiperidin-4-yl)methoxyiminomethyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C28H30N4O5 |
| —— | 3-[2-[2-carboxy-2-[3-(3-oxobutoxy)propanoylamino]ethyl]sulfanylcyclobutyl]sulfanyl-2-(methylamino)propanoic acid;[(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-aminoacetate | —— | C40H49N5O12S2 |
| —— | [(19S)-19-ethyl-19-hydroxy-10-[[methyl(methylamino)amino]methyl]-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[[4-(docosa-4,7,10,13,16,19-hexaenoylamino)phenyl]methyl]piperazine-1-carboxylate | —— | C57H69N7O7 |
| —— | N-[[1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[2-[2-[[(2S)-1-[[(2S)-6-amino-1-(4-methylanilino)-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethoxy]acetyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl]-4-[(3-methyl-2,5-dioxopyrrolidin-1-yl)methyl]cyclohexane-1-carboxamide;[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] ethyl carbonate | —— | C85H116N12O23 |
| —— | (19S)-7-(butoxyiminomethyl)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione | —— | C25H25N3O5 |
| —— | [(19R)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-aminoacetate;hydrochloride | —— | C22H20ClN3O5 |
| —— | 2-amino-N-[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-8-yl]acetamide | —— | C22H20N4O5 |
| —— | 9-Glycineamido-20(S)-camptothecin.HCl | —— | C22H21ClN4O5 |
| —— | [(19R)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-aminoacetate | —— | C22H19N3O5 |
| —— | (19R)-19-ethyl-19-hydroxy-10-[(2-methylpropan-2-yl)oxyiminomethyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C25H25N3O5 |
| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] N-octadeca-9,12-dienoxycarbamate | —— | C41H53N3O7 |
| —— | Tert-butyl [10,19-diethyl-19-[3-methyl-2-[[2-[2-[(2-methyl-4-pentan-2-yloxybutan-2-yl)amino]-2-oxoethoxy]acetyl]amino]butoxy]carbonyloxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] carbonate | —— | C47H64N4O13 |
| —— | ethane;(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C22H22N2O4 |
| —— | (19S)-19-(dimethylphosphoryloxymethoxy)-19-ethyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione;(19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl)oxymethyl phosphate | —— | C44H40N4O14P2-2 |
| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[[3-[2-[3-[3-[bis(phosphanyl)methylsulfanyl]-2,5-dihydroxypyrrol-1-yl]propanoylamino]ethoxy]propanoylamino]methyl]cyclohexane-1-carboxylate | —— | C43H53N5O11P2S |
| —— | (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;ethyl trifluoromethanesulfonate | —— | C26H28F3N3O8S |
| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 3-[3-[bis(phosphanyl)methylsulfanyl]-2,5-dihydroxypyrrol-1-yl]propanoate | —— | C30H31N3O8P2S |
| —— | 23-Amino-10-ethyl-18-fluoro-10-methoxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione | —— | C25H24FN3O4 |
| —— | 10-Benzyl-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione | —— | C27H22N2O5 |
| —— | (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;formonitrile | —— | C21H17N3O5 |
| —— | [(19S)-10,19-diethyl-19-(methylcarbamoyloxy)-14,18-dioxo-17-oxa-3-azapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;[(19S)-19-ethyl-19-hydroxy-10-(methoxymethyl)-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate | —— | C69H80N8O14 |
| —— | [2-[[6-Amino-2-[[2-[2-[[2-methyl-4-[4-(4-methyltriazol-1-yl)butan-2-yloxy]butan-2-yl]amino]-2-oxoethoxy]acetyl]amino]hexanoyl]amino]-3-methylbutyl] (10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) carbonate | —— | C50H69N9O12 |
| —— | [2-[2-[[2-(2-Amino-2-oxoethoxy)acetyl]amino]octanoylamino]-3-methylbutyl] (7,10,19-triethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) carbonate | —— | C42H55N5O10 |
| —— | [(19S)-19-ethyl-19-hydroxy-14,18-dioxo-10-[[3-(propylideneamino)prop-1-ynylamino]methyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[[4-(docosa-4,7,10,13,16,19-hexaenoylamino)phenyl]methyl]piperazine-1-carboxylate | —— | C61H71N7O7 |
| —— | N-(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-8-yl)acetamide | —— | C22H19N3O5 |
| —— | (19S)-10,19-diethyl-19-hydroxy-7-octadeca-9,12-dienoxycarbothioyloxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione | —— | C41H52N2O6S |
| —— | [(19S)-8-[(dimethylamino)methyl]-19-ethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-[(E)-(4-methyl-2,5,7-trinitrofluoren-9-ylidene)amino]oxyacetate | —— | C39H31N7O13 |
| —— | [19-[2-[[2-[2-[2-(2-azidoethoxy)ethylamino]-2-oxoethoxy]acetyl]amino]-3-methylbutoxy]carbonyloxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy-methylborinic acid;(19-carbonochloridoyloxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl)oxy-methylborinic acid;4-[(2,5-dioxopyrrol-1-yl)methyl]-N-prop-2-ynylcyclohexane-1-carboxamide | —— | C76H86B2ClN11O22 |
| —— | fluorophosphane;[3-[2-hydroxy-1-[1-hydroxy-3-(2-hydroxy-1-methoxyethoxy)propan-2-yl]oxyethoxy]-2-[2-hydroxy-1-(3-hydroxy-2-methylpropoxy)ethoxy]propyl] 4-[[2-[[(19R)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl]oxy]-2-oxoethyl]amino]-4-oxobutanoate | —— | C43H59FN3O19P |
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