喜树碱
相关化合物
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | (19S)-19-ethyl-10-[[[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methyldisulfanyl]methyl]-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | 1422210-75-0 | C42H34N4O8S2 |
| —— | (4S)-11-{2-[dimethyl-(2-oxo-2H-pyridin-1-ylmethyl)-silanyl]-ethyl}-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 1142937-07-2 | C30H31N3O5Si |
| —— | (4S)-11-(2-{dimethyl-[3-(2-oxo-2H-pyridin-1-yl)-propyl]-silanyl}-ethyl)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 1142936-78-4 | C32H35N3O5Si |
| —— | (9S)-1-butyl-9-ethyl-9-hydroxy-1H,12H-pyrano[3'',4'':6',7']indolizino[1',2':6,5]-pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione | 534605-76-0 | C25H24N4O4 |
| —— | (9S)-9-ethyl-9-hydroxy-1-(3-methylbutyl)-1H,12H-pyrano[3",4":6',7']indolizino-[1',2':6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione | 538374-59-3 | C26H26N4O4 |
| —— | (9S)-9-ethyl-9-hydroxy-1-phenethyl-1H,12H-pyrano[3",4":6',7']indolizino[1',2':6,5]-pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione | 538374-56-0 | C29H24N4O4 |
| —— | (9S)-9-ethyl-9-hydroxy-2-methyl-1-pentyl-1H, 12H-pyrano[3",4":6',7']indolizino-[1',2':6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione | 534605-80-6 | C27H28N4O4 |
| —— | 7-(2'-trimethylsilylethyl)-10-hydroxycamptothecin | 276250-51-2 | C25H28N2O5Si |
| —— | 7-(2'-(trimethylsilanyl)ethyl)-10-(dimethylcarbamoyloxy)-camptothecin | 1142812-22-3 | C28H33N3O6Si |
| —— | (4S)-11-{2-[dimethyl-(3-[1,2,4-triazol-1-yl]-propyl)-silanyl]-ethyl}-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 1142936-74-0 | C29H33N5O4Si |
| —— | (4S)-11-[2-(dimethyl-[1,2,4]triazol-1-ylmethylsilanyl)-ethyl]-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 1142937-05-0 | C27H29N5O4Si |
| —— | (4S)-11-[2-(dimethyl-pyrrolidin-1-ylmethyl-silanyl)-ethyl]-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 1142937-08-3 | C29H35N3O4Si |
| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate;hydrochloride | —— | C48H61ClFN7O12 |
| —— | [(19S)-19-ethyl-8-nitro-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 3-nitrobenzoate | —— | C27H18N4O9 |
| —— | (18S)-18-ethyl-2-[ethyl(pyridin-4-ylmethyl)amino]-18-hydroxy-6,9,20-trioxa-13,24-diazahexacyclo[12.11.0.03,12.05,10.015,24.017,22]pentacosa-1,3,5(10),11,13,15,17(22)-heptaene-19,23-dione | —— | C30H28N4O6 |
| —— | [(19S)-8-amino-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] propanoate | —— | C23H21N3O5 |
| —— | 4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;trihydrate;hydrochloride | —— | C47H57Cl2N7O13S2 |
| —— | (19S)-19-ethyl-19-hydroxy-8-nitro-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;5-fluoro-1H-pyrimidine-2,4-dione | —— | C24H18FN5O8 |
| —— | (19S)-19-ethyl-7,19-dihydroxy-12-(2,2,2-trifluoroethoxy)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione | —— | C22H17F3N2O6 |
| —— | (19S)-19-ethyl-7-fluoro-19-hydroxy-10-(2-trimethylsilylethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione | —— | C25H27FN2O4Si |
| —— | (19S)-5,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,9,15(20)-hexaene-14,18-dione;[(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 6-[[2-[methyl(prop-2-enoyl)amino]acetyl]amino]hexanoate | —— | C54H56N6O11 |
| —— | [(19S)-8-amino-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-hydroxybenzoate | —— | C27H21N3O6 |
| —— | 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate | —— | C46H51N7O9 |
| —— | (9S)-9-ethyl-9-hydroxy-2-hydroxymethyl-1-(3-methylbutyl)-1H,12H-pyrano[3",4':6',7']indolizino[1',2':6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione | 538374-85-5 | C27H28N4O5 |
| —— | (19S)-5,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),4,6,9,15(20)-hexaene-8,14,18-trione | —— | C22H20N2O5 |
| —— | (19R)-19-ethyl-7,19-dihydroxy-8-(methylaminomethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione | —— | C22H21N3O5 |
| —— | 5-[[1-[[(19R)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxycarbonyl]piperidin-4-yl]amino]pentanoic acid | —— | C33H38N4O8 |
| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2,6-diaminohexanoate | —— | C26H28N4O5 |
| —— | [(19S)-10,19-diethyl-16,19-dihydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate | —— | C33H38N4O7 |
| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] (Z)-octadec-9-enoate | —— | C40H52N2O6 |
| —— | [(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl] tetradecanoate | —— | C34H42N2O6 |
| —— | (2S)-2-hydroxy-2-[7-(hydroxymethyl)-12-[(4-methylpiperazin-1-yl)methyl]-8-oxo-16,19-dioxa-2,9-diazapentacyclo[11.8.0.03,11.04,9.015,20]henicosa-1(21),2,4,6,11,13,15(20)-heptaen-6-yl]butanoic acid | —— | C28H32N4O7 |
| —— | Acetic acid;5-ethyl-14-[2-(ethylamino)ethyl]-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaene-6,10-dione | —— | C2H4O2*C25H25N3O6 |
| —— | [(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-10-yl]methyl 2-(4-fluorophenoxy)acetate | —— | C29H23FN2O7 |
| —— | 5-Ethyl-14-[2-(ethylamino)ethyl]-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaene-6,10-dione | —— | C25H25N3O6 |
| —— | N-[2-[(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl)oxy]ethyl]-1-methylpyrrole-2-carboxamide | —— | C28H26N4O6 |
| —— | (19S)-19-ethyl-19-hydroxy-10-[(4-methylsulfanylphenyl)iminomethyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C28H23N3O4S |
| —— | methyl 2-acetamido-3-[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-8-yl]propanoate | —— | C26H25N3O7 |
| —— | (5S)-5-ethyl-5-hydroxy-14-[(3-methylimidazol-3-ium-1-yl)methyl]-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaene-6,10-dione | —— | C26H23N4O6+ |
| —— | (19R)-19-ethyl-19-hydroxy-10-triethylsilyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C26H30N2O4Si |
| —— | (10S)-10-ethyl-22,22,23,23-tetrafluoro-10,19-dihydroxy-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16(24),17,19-heptaene-5,9-dione | —— | C23H16F4N2O5 |
| —— | (5S)-5-ethyl-14-[(3-methylimidazol-3-ium-1-yl)methyl]-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-5-olate | —— | C26H22N4O6 |
| —— | (19S)-19-ethyl-19-hydroxy-6-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione | —— | C21H18N2O4 |
| —— | (2R)-2-amino-3-methylselanylpropanoic acid;[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate | —— | C37H47N5O8Se |
| —— | [(19S)-8-amino-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-(trifluoromethyl)benzoate | —— | C28H20F3N3O5 |
| —— | [(19S)-19-ethyl-8-nitro-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-nitrobenzoate | —— | C27H18N4O9 |
| —— | [(19S)-19-ethyl-8-nitro-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-cyanobenzoate | —— | C28H18N4O7 |
| —— | [(19S)-8-amino-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-nitrobenzoate | —— | C27H20N4O7 |
| —— | [(19S)-8-amino-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-fluorobenzoate | —— | C27H20FN3O5 |
| —— | [(19S)-8-amino-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 4-cyanobenzoate | —— | C28H20N4O5 |
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