喜树碱
相关化合物
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | L-valyl-N-(5-{[(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]oxy}-2,2-difluoro-5-oxopentyl)-N<sup>5</sup>-carbamoyl-L-ornithinamide | 1609075-29-7 | C36H42BrF2N7O8 |
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| —— | 4-[[(2S)-1-[[(2S)-1-[[5-[[(19S)-8-bromo-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxy]-2,2-difluoro-5-oxopentyl]amino]-5-hydrazinyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid | —— | C39H46BrF2N7O10 |
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| —— | N-[6-(2,5-dioxopyrrolidin-1-yl)hexanoyl]-L-valyl-N-[4-({[(5-{[(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]oxy}-2,2-difluoro-5-oxopentyl)carbamoyl]oxy}methyl)phenyl]-N<sup>5</sup>-carbamoyl-L-ornithinamide | 1609075-33-3 | C54H60BrF2N9O13 |
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| —— | 4-O-[(19S)-8-bromo-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 1-O-[[4-[[5-(carbamoylamino)-2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl] piperazine-1,4-dicarboxylate | —— | C54H61BrN10O13 |
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| —— | (4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl 5-[((tert-butoxy)carbonyl)amino]-4,4-difluoropentanoate | 1609075-12-8 | C30H30BrF2N3O7 |
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| —— | N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N-(5-{[(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1 ,2-b]quinolin-4-yl]oxy}-2,2-difluoro-5-oxopentyl)-N<sup>5</sup>-carbamoyl-L-ornithinamide | 1609075-31-1 | C46H53BrF2N8O11 |
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| —— | [(19S)-8-bromo-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 5-[(4-aminophenyl)methoxycarbonylamino]-4,4-difluoropentanoate | —— | C33H29BrF2N4O7 |
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| —— | (2S)-5-[[2-[[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxy]-2-oxoethyl]amino]-2-(hexadecanoylamino)-5-oxopentanoic acid | —— | C45H60N4O10 |
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| —— | tert-butyl 2-[(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl]acetate | —— | C26H26N2O6 |
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| —— | tert-butyl 2-[[2-[[4-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-4-oxobutanoyl]amino]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]amino]octadecanoate | —— | C59H87N5O12 |
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| —— | 2-[[4-[[(19S)-19-[4-(1-carboxypentylamino)-4-oxobutanoyl]oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-4-oxobutanoyl]amino]hexanoic acid | —— | C42H50N4O13 |
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| —— | (2S)-5-[[2-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-2-oxoethyl]amino]-2-(hexadecanoylamino)-5-oxopentanoic acid | —— | C45H60N4O10 |
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| —— | tert-butyl 2-[[6-amino-2-[[4-[[(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl]oxy]-4-oxobutanoyl]amino]hexanoyl]amino]octadecanoate | —— | C52H75N5O9 |
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| —— | 2-[[6-amino-2-[[4-[[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxy]-4-oxobutanoyl]amino]hexanoyl]amino]octadecanoic acid | —— | C50H71N5O10 |
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| —— | (2S)-5-[[2-[[(19S)-10-[(dimethylamino)methyl]-19-ethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxy]-2-oxoethyl]amino]-2-(hexadecanoylamino)-5-oxopentanoic acid | —— | C46H63N5O10 |
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| —— | tert-butyl (2S)-5-[[2-[[(19S)-19-ethyl-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-19-yl]oxy]-2-oxoethyl]amino]-2-(hexadecanoylamino)-5-oxopentanoate | —— | C48H66N4O9 |
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| —— | 2-[[6-amino-2-[[4-[[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-4-oxobutanoyl]amino]hexanoyl]amino]octadecanoic acid | —— | C50H71N5O10 |
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| —— | (2S)-2-[[6-[[(19S)-19-[4-[[(1S)-1-carboxy-3-methylbutyl]amino]-4-oxobutanoyl]oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-6-oxohexanoyl]amino]-4-methylpentanoic acid | —— | C44H54N4O13 |
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| —— | 2-[[6-amino-2-[[4-[[(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl]oxy]-4-oxobutanoyl]amino]hexanoyl]amino]octadecanoic acid | —— | C48H67N5O9 |
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| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 2-(5-oxohexanoylamino)acetate | —— | C28H27N3O7 |
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| —— | (19S)-8-[(dimethylamino)methyl]-19-ethyl-7-hydroxy-19-propan-2-yloxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione | —— | C26H29N3O5 |
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| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 5-oxohexanoate | —— | C26H24N2O6 |
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| —— | (18S)-18-ethyl-2-[(4-methylpiperazin-1-yl)methyl]-18-propan-2-yloxy-6,9,20-trioxa-13,24-diazahexacyclo[12.11.0.03,12.05,10.015,24.017,22]pentacosa-1,3,5(10),11,13,15,17(22)-heptaene-19,23-dione | —— | C31H36N4O6 |
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| —— | (10S,23S)-23-amino-10-ethyl-18-fluoro-19-methyl-10-propan-2-yloxy-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione | —— | C27H28FN3O4 |
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| —— | (19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl) 2-[[5-[[(5R)-5-(methylamino)-6-oxoheptyl]amino]-4-oxopentanoyl]amino]acetate | —— | C35H41N5O8 |
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| —— | N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-phenylalanyl-N-(5-{[(4S)-10-bromo-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]oxy}-2,2-difluoro-5-oxopentyl)-L-leucinamide | 1609075-37-7 | C50H53BrF2N6O10 |
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| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] dihydrogen phosphite | —— | C20H17N2O6P |
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| —— | (19S)-19-ethyl-19-hydroxy-7-morpholin-4-yl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione | —— | C24H23N3O5 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxymethyl 1-(propan-2-ylcarbamoyloxymethyl)pyridin-1-ium-3-carboxylate | —— | C34H35N4O9+ |
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| —— | [(19S)-10,19-diethyl-7-[(2-methylpropan-2-yl)oxycarbonyloxy]-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 4-butoxybutanoate | —— | C35H42N2O9 |
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| —— | [(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 4-(hydrazinecarbonyloxy)butanoate | —— | C27H28N4O8 |
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| —— | [(19S)-10,19-diethyl-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 4-hydroxybutanoate | —— | C27H28N2O6 |
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| —— | [(19S)-10,19-diethyl-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] pentanoate | —— | C28H30N2O5 |
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| —— | 10,19-Diethyl-19-hydroxy-7-(4-nitrophenyl)peroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione | —— | C28H23N3O8 |
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| —— | (10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl) 4-[2-[5-[[(E)-amino-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)methyl]amino]indol-1-yl]ethyl]piperidine-1-carboxylate | —— | C48H50N6O8 |
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| —— | t-butyl (4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-4,9-diyl) (4-nitrophenyl) dicarbonate | —— | C34H31N3O11 |
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| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 6-[4-[[2-[[2-(hydroxymethyl)-2-(prop-2-ynoxymethyl)butoxy]methyl]-2-(propan-2-yloxymethyl)butoxy]methyl]triazol-1-yl]hexanoate | —— | C47H61N5O10 |
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| —— | (10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl) 4-[2-[5-[[(E)-amino-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)methyl]-carbamoylamino]indol-1-yl]ethyl]piperidine-1-carboxylate | —— | C49H51N7O9 |
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| —— | Cyclohexyl (10,19-diethyl-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) carbonate | —— | C30H32N2O6 |
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| —— | (10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl) N-[2-[[(5Z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-pyridin-3-yl-1H-1,2,4-triazole-3-carbonyl]amino]ethyl]-N-methylcarbamate | —— | C43H42N8O9 |
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| —— | 1-O-tert-butyl 4-O-(10,19-diethyl-7-methyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) piperidine-1,4-dicarboxylate | —— | C34H39N3O7 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;[(2S,3S,4R,5R)-4-hydroxy-2,5-bis(hydroxymethyl)-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-3-yl] hydrogen sulfate | —— | C45H60N4O20S |
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| —— | (19S)-19-ethyl-19-hydroxy-8-nitro-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione | —— | C40H30N6O12 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;[(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-disulfonatooxy-2,5-bis(sulfonatooxymethyl)oxolan-2-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)oxan-4-yl] sulfate | —— | C45H52N4O41S8-8 |
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| —— | 4-[[10,19-Diethyl-7-[(2-methylpropan-2-yl)oxycarbonyloxy]-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxycarbonyloxy]piperidine-1-carboxylic acid | —— | C34H37N3O11 |
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| —— | (19R)-19-ethyl-19-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C26H26N2O9 |
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| —— | 12-Hydroxycamptothecin | —— | C20H16N2O5 |
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| —— | 12-Acetamidocamptothecin | —— | C22H19N3O5 |
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| —— | 11-Methoxycamptothecin | —— | C21H18N2O5 |
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| —— | 19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),4,6,9,15(20)-hexaene-8,14,18-trione | —— | C20H16N2O5 |
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