喜树碱
相关化合物
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | 2-hydroxy-2-(8-ethoxymethyl-9-oxo-9,11-dihydro-indolizino[1,2-<i>b</i>]quinolin-7-yl)-succinic acid diethyl ester | 58586-39-3 | C26H28N2O7 |
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| —— | [4-[[(2S)-6-amino-2-[[(2S)-2-[6-[3-(2-hydroxyethylsulfanyl)-2,5-dioxopyrrolidin-1-yl]hexanoylamino]-3-phenylpropanoyl]amino]hexanoyl]amino]phenyl]methyl [(19R)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] carbonate | —— | C55H61N7O12S |
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| —— | 4-O-[(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] 1-O-[(1S,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl] butanedioate | —— | C39H42N2O11 |
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| —— | 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid;[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate | —— | C47H57Cl2N5O8 |
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| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] [(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl] carbonate | —— | C41H48N2O6 |
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| —— | (19S)-19-ethyl-19-[[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenoxy]methoxy]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C41H50N2O5 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[[3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]methyl]cyclohexane-1-carboxylate | —— | C46H62N4O13 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]cyclohexane-1-carboxylate | —— | C35H41N3O8 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[4-(2,5-dioxopyrrol-1-yl)butanoylamino]benzoate | —— | C37H32N4O9 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[[3-[2-[2-[2-[2-[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]methyl]cyclohexane-1-carboxylate | —— | C53H67N5O14 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-(aminomethyl)cyclohexane-1-carboxylate | —— | C30H33N3O6 |
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| —— | [(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 3-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]butyl carbonate | —— | C44H49N7O11 |
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| —— | [(1S)-1-chloroethyl] (10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl) carbonate | —— | C25H23ClN2O7 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-[[3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoylamino]methyl]cyclohexane-1-carboxylate | —— | C41H54N4O11 |
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| —— | (2R)-2-[[4-[[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxy]-4-oxobutanoyl]amino]-4-methylpentanoic acid | —— | C32H35N3O9 |
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| —— | (2R)-2-[[4-[[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxy]-4-oxobutanoyl]amino]-3-phenylpropanoic acid | —— | C35H33N3O9 |
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| —— | 2-[[4-[[(19S)-19-[4-[(1-carboxy-2-phenylethyl)amino]-4-oxobutanoyl]oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-4-oxobutanoyl]amino]-3-phenylpropanoic acid | —— | C48H46N4O13 |
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| —— | 2-[4-[(19S)-19-[4-(1-carboxyheptylamino)-4-oxobutanoyl]oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]butyl]octanoic acid | —— | C46H61N3O10 |
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| —— | tert-butyl 2-[4-[(19S)-10,19-diethyl-19-[4-[[1-[(2-methylpropan-2-yl)oxy]-1-oxooctan-2-yl]amino]-4-oxobutanoyl]oxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]butyl]octanoate | —— | C54H77N3O10 |
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| —— | (2R)-2-[[4-[[(19S)-19-[4-[[(1R)-1-carboxy-3-methylbutyl]amino]-4-oxobutanoyl]oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-4-oxobutanoyl]amino]-4-methylpentanoic acid | —— | C42H50N4O13 |
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| —— | (2S)-2-[[4-[[(19S)-19-[4-[[(1S)-1-carboxy-3-methylbutyl]amino]-4-oxobutanoyl]oxy-10,19-diethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl]oxy]-4-oxobutanoyl]amino]-4-methylpentanoic acid | —— | C42H50N4O13 |
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| —— | [4-[(2-Acetamido-6-aminohexyl)amino]phenyl]methyl (10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) carbonate | —— | C38H43N5O8 |
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| —— | (10,19-Diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) [3-methyl-2-[[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[[[4-[(3-methyl-2,5-dioxopyrrolidin-1-yl)methyl]-2-oxocyclohexyl]methylamino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetyl]amino]butyl] carbonate | —— | C66H93N9O21 |
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| —— | (19S)-19-ethyl-19-(oxan-2-yloxy)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione | —— | C25H24N2O5 |
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| —— | (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid;(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride | —— | C36H42Cl3N5O7 |
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| —— | 3-[[(19S)-19-ethyl-7-methoxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-19-yl]oxy]propanoic acid | —— | C24H22N2O7 |
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| —— | [2-[[6-Amino-2-[[2-(2-amino-2-oxoethoxy)acetyl]amino]hexanoyl]amino]-3-methylbutyl] [10,19-diethyl-7-[2-[hydroxy(dimethyl)silyl]-2-methylpropyl]-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] carbonate | —— | C44H62N6O11Si |
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| —— | [4-[[6-Amino-2-[[2-(2-amino-2-oxoethoxy)acetyl]amino]hexanoyl]amino]phenyl]methyl (10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) carbonate | —— | C40H44N6O11 |
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| —— | [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 2-methylsulfanylethyl carbonate | —— | C26H26N2O7S |
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| —— | [(2S,3R,4R,5R)-5-(6-acetamido-2-chloropurin-9-yl)-4-fluoro-3-methyloxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C33H30ClFN7O9P |
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| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] [(2S,3S,5R)-3-methyl-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate | —— | C31H31N4O10P |
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| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] [(2S,3S)-3-methyloxolan-2-yl]methyl hydrogen phosphate | —— | C26H27N2O8P |
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| —— | [(2S,3S,5R)-5-[(8R)-6-acetyl-8-methyl-7,8-dihydroimidazo[4,5-d][1,3]diazepin-3-yl]-3-methyloxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C35H37N6O9P |
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| —— | [(2S,3S,5R)-5-(6-acetamido-2-chloropurin-9-yl)-3-methyloxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C33H31ClN7O9P |
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| —— | [(2S,3S,5R)-5-(4-acetamido-2-oxo-1,3,5-triazin-1-yl)-3-methyloxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C31H31N6O10P |
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| —— | [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] [(2S,3S,5R)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-methyloxolan-2-yl]methyl hydrogen phosphate | —— | C30H28FN4O10P |
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| —— | [(2R,3S,5R)-5-(2,6-diaminopurin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C30H29N8O9P |
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| —— | [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C30H27FN7O10P |
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| —— | [(2S,3R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-4,4-difluoro-3-methyloxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C32H30F2N5O10P |
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| —— | [(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C28H27N6O11P |
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| —— | Dix-904 | 1332459-10-5 | C30H28N7O9P |
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| —— | [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C29H27N4O12P |
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| —— | [(2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C30H27FN7O9P |
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| —— | [(2R,3R,4R,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] hydrogen phosphate | —— | C30H26ClFN7O9P |
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| —— | (10,19-Diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl) carbonochloridate | —— | C23H19ClN2O6 |
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| —— | [(19S)-10-[(dimethylamino)methyl]-19-ethyl-14,18-dioxo-7-prop-2-enoxycarbonyloxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] prop-2-enyl carbonate | —— | C31H31N3O9 |
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| —— | [(19S)-8-bromo-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 2-[1-[[[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]pentanoyl]amino]phenyl]methoxycarbonylamino]methyl]cyclohexyl]acetate | —— | C53H65BrN8O12 |
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| —— | 2-[[5-[[(19S)-19-ethyl-7-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-19-yl]oxy]-5-oxopentanoyl]amino]octadecanoic acid | —— | C49H67N3O10 |
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| —— | (2S)-5-[[2-[[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxy]-2-oxoethyl]amino]-5-oxo-2-(pentadecanoylamino)pentanoic acid | —— | C44H58N4O10 |
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| —— | [(19S)-8-bromo-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] 5-[[(2S)-5-(carbamoylamino)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]pentanoyl]amino]-4,4-difluoropentanoate | —— | C41H50BrF2N7O10 |
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