抗震颤麻痹药也称为抗帕金森病药。震颤麻痹症是一种由于锥体外系病变引起的运动性疾病,主要是因黑质中的多巴胺神经元发生变性,导致锥体外系的多巴胺含量不足,从而使胆碱能神经功能相对占优势,引发一系列症状。
抗震颤麻痹药主要分为两大类:拟多巴胺药和中枢性抗胆碱药。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| 金刚烷胺 | 1-Adamantanamine | 768-94-5 | C10H17N |
| 邻甲苯海明 | orphenadrine | 83-98-7 | C18H23NO |
| 赛克立明 | cycrimine | 77-39-4 | C19H29NO |
| 苯海索 | trihexyphenidyl | 144-11-6 | C20H31NO |
| 苄丝肼 | benserazide | 322-35-0 | C10H15N3O5 |
| 累匹利洛 | Ropinirole | 91374-21-9 | C16H24N2O |
| 盐酸金刚烷胺 | amantadine hydrochloride | 665-66-7 | C10H18N*Cl |
| 盐酸苯海索 | trihexylphenidyl hydrochloride | 52-49-3 | C20H31NO*ClH |
| 盐酸卞丝肼 | benserazide hydrochloride | 14919-77-8 | C10H15N3O5*ClH |
| 甲磺酸溴隐亭 | Cycloset | 22260-51-1 | CH4O3S*C32H40BrN5O5 |
| 甲基多巴 | methyldopa | 555-30-6 | C10H13NO4 |
| 环苯咯丙醇 | procyclidine | 77-37-2 | C19H29NO |
| 溴隐亭 | Bromocriptine | 25614-03-3 | C32H40BrN5O5 |
| 比哌立登 | biperiden | 514-65-8 | C21H29NO |
| 托利卡因 | tolycaine | 3686-58-6 | C15H22N2O3 |
| 左旋多巴 | levodopa | 59-92-7 | C9H11NO4 |
| 培高利特 | pergolide | 66104-22-1 | C19H26N2S |
| 吡贝地尔 | piribedil | 3605-01-4 | C16H18N4O2 |
| 叔丁哌苯 | budipine | 57982-78-2 | C21H27N |
| 双环哌丙醇盐酸盐 | biperiden hydrochloride | 1235-82-1 | C21H29NO*ClH |
| 单唾液酸神经节苷酯 | Monosialogangloside GM1 | 37758-47-7 | C73H131N3O31 |
| 二乙嗪 | diethazine | 60-91-3 | C18H22N2S |
| 乳酸比哌立登 | Biperiden Lactate | 7085-45-2 | C24H35NO4 |
| 乙基苯海拉明 | Ethylbenzhydramin | 642-58-0 | C19H25NO |
| 乙丙嗪 | 10-(2-diethylaminopropyl)phenothiazine | 522-00-9 | C19H24N2S |
| 三唾液酸神经节甘酯GT1B | Trisialoganglioside GT1b | 59247-13-1 | C88H157N5O44 |
| 4-(5-己基-2-嘧啶基)-苯甲酸 | (+)-biperiden | 514-65-8 | C21H29NO |
| 3,5-二甲基金刚胺 | memantine* | 19982-08-2 | C12H21N |
| 2-甲基-3-(3,4-二羟基苯基)-DL-丙氨酸 | alpha-methyldopa | 55-40-3 | C10H13NO4 |
| 1-甲基-3-(9H-硫杂蒽-9-甲基)哌啶美噻吨 | Tremonil | 4969-02-2 | C20H23NS |
| —— | (4S)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid;hydrochloride | 79547-78-7 | C26H30ClFN2O2 |
| —— | ganglioside G<sub>M1</sub> | 37758-47-7 | C73H131N3O31 |
| —— | (+)-1-cyclohexyl-1-phenyl-3-piperidino-propan-1-ol; hydrochloride | 52-49-3 | C20H31NO*ClH |
| —— | Memantine | 19982-08-2 | C12H21N |
| —— | 1-amino-3,5-dimethyladamantane maleate | 19982-08-2 | C4H4O4*C12H21N |
| —— | benzatropine mesylate | 132-17-2 | CH4O3S*C21H25NO |
| —— | Levocabastine hydrochloride | 79516-67-9 | C26H29FN2O2*ClH |
| —— | Amantadine | 768-94-5 | C10H17N |
| —— | (+)-1-cyclohexyl-1-phenyl-3-piperidino-propan-1-ol | 144-11-6 | C20H31NO |