毒理性
◉ 母乳喂养期间使用总结：由于眼部吸收有限，预计左卡巴斯汀不会对哺乳婴儿产生任何不良反应。为了显著减少使用眼药水后药物到达母乳的量，可以在眼角处对泪点施加压力1分钟或更长时间，然后用吸收性纸巾去除多余的溶液。
◉ 对哺乳婴儿的影响：截至修订日期，未找到关于左卡巴斯汀的相关已发布信息。在一项电话随访研究中，母亲报告有10%的婴儿在接触各种抗组胺药后出现烦躁和肠绞痛症状，1.6%的婴儿出现嗜睡。所有反应均未需要医疗关注。
◉ 对泌乳和母乳的影响：在非哺乳期妇女和产后早期妇女中，通过注射给予相对高剂量的抗组胺药可以降低基础血清催乳素。然而，吸吮诱导的催乳素分泌不会受到产后母亲抗组胺药预处理的影响。尚未研究较低口服剂量的抗组胺药是否对血清催乳素有相同的影响，或者对催乳素的影响是否对母乳喂养成功有任何影响。在已建立泌乳的母亲中，催乳素水平可能不会影响她的哺乳能力。
◉ Summary of Use during Lactation:Because absorption from the eye is limited, levocabastine would not be expected to cause any adverse effects in breastfed infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
◉ Effects in Breastfed Infants:Relevant published information on levocabastine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.
◉ Effects on Lactation and Breastmilk:Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
来源:Drugs and Lactation Database (LactMed)
