非甾抗炎药
非甾体类抗炎药依据化学结构可分为水杨酸类、丙酸类、乙酸类、灭酸类和烯酸类，它们主要通过抑制环氧合酶（COX），阻断花生四烯酸向前列腺素的转化，从而发挥解热、镇痛和抗炎作用。人体内存在两种环氧合酶：COX-1 和 COX-2。COX-1 主要分布在胃肠道、肾脏和血小板等组织中，抑制后可能引起胃肠道损伤等不良反应；而 COX-2 主要在炎症组织中分布，是一种诱导性酶，在炎症过程中发挥重要作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 布洛芬 | ibuprofen | 15687-27-1 | C13H18O2 |
|
| 布替布芬 | 2-(4-isobutyl-phenyl)-butyric acid | 55837-18-8 | C14H20O2 |
|
| 屈昔康 | droxicam | 90101-16-9 | C16H11N3O5S |
|
| 尼美舒利 | nimesulide | 51803-78-2 | C13H12N2O5S |
|
| 安吡昔康 | 4-[1-(Ethoxycarbonyloxy)ethoxy]-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide | 99464-64-9 | C20H21N3O7S |
|
| 季铵盐-73 | Thiazolium, 3-heptyl-2-[(3-heptyl-4-methyl-2(3H)-thiazolylidene)methyl]-4-methyl-, iodide (1:1) | 15763-48-1 | C23H39N2S2*I |
|
| 奥沙普秦 | 3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid | 21256-18-8 | C18H15NO3 |
|
| 塞来西布 | 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide | 169590-42-5 | C17H14F3N3O2S |
|
| 噻洛芬酸 | tiaprofenic acid | 33005-95-7 | C14H12O3S |
|
| 呋喃洛芬 | furaprofen | 67700-30-5 | C17H14O3 |
|
| 吲哚美辛 | [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid | 53-86-1 | C19H16ClNO4 |
|
| 吡罗昔康Β环糊精 | 1:2.5 piroxicam-β-cyclodextrin complex | 96684-40-1 | C15H13N3O4S*2C42H70O35 |
|
| 吡罗昔康 | Piroxicam | 36322-90-4 | C15H13N3O4S |
|
| 吡咯布洛芬 | pirprofen | 31793-07-4 | C13H14ClNO2 |
|
| 右旋酮洛芬氨丁三醇 | Enantyum | 156604-79-4 | C4H11NO3*C16H14O3 |
|
| 双氯芬酸钾 | Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, monopotassiumsalt | 15307-81-0 | C14H11Cl2KNO2 |
|
| 双氯芬酸钠 | Diclofenac sodium salt, analytical standard | 15307-79-6 | C14H11Cl2NNaO2 |
|
| 双氯芬酸二乙胺盐 | diclofenac diethylamine | 78213-16-8 | C4H11N*C14H11Cl2NO2 |
|
| 双氯芬酸 | Diclofenac | 15307-86-5 | C14H11Cl2NO2 |
|
| 卡洛芬 | 2-(6-chloro-carbazol-2-yl)-propionic acid | 53716-49-7 | C15H12ClNO2 |
|
| 保泰松 | Phenylbutazone | 50-33-9 | C19H20N2O2 |
|
| 依托芬那酯 | etofenamate | 30544-47-9 | C18H18F3NO4 |
|
| 依托度酸 | etodolac | 41340-25-4 | C17H21NO3 |
|
| 依匹唑 | epirizole | 18694-40-1 | C11H14N4O2 |
|
| 二氟尼柳 | 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid | 22494-42-4 | C13H8F2O3 |
|
| 丹皮酚 | 1-(2-hydroxy-4-methoxyphenyl)ethanone | 552-41-0 | C9H10O3 |
|
| 丝美辛 | (L)-N-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetyl]-serine | 57645-05-3 | C22H21ClN2O6 |
|
| 三水杨酸胆碱镁 | Magnesium;2-carboxyphenolate;2-hydroxybenzoate;2-hydroxyethyl(trimethyl)azanium | 85169-11-5 | C26H29MgNO10 |
|
| 丁苯羟酸 | bufexamac | 2438-72-4 | C12H17NO3 |
|
| 丁基环已基巴比妥 | bucolome | 841-73-6 | C14H22N2O3 |
|
| N-2,3-二氯苯基氨基苯甲酸 | N-(2,3-Dichlor-phenyl)-anthranilsaeure | 4295-55-0 | C13H9Cl2NO2 |
|
| 5,6,7,8-四氢-N-[2-(2H-四唑-5-基)苯基]-1-萘胺 | BL-1249 | 18200-13-0 | C17H17N5 |
|
| 2-苯基-4-喹啉羧酸 | cinchophen | 132-60-5 | C16H11NO2 |
|
| (R)-2-氟比洛芬 氟比洛芬 | (R)-flurbiprofen | 51543-40-9 | C15H13FO2 |
|
| (R)-(-)-布洛芬 | (R)-ibuprofene | 51146-57-7 | C13H18O2 |
|
| (E)-3,5-二羟基-4-异丙基二苯乙烯 | 2-isopropyl-5-[(E)-2-phenylethenyl]benzene-1,3-diol | 79338-84-4 | C17H18O2 |
|
| —— | Fenoprofen (Calcium hydrate) | 71720-56-4 | C30H30CaO8 |
|
| —— | gold(1+);(2S,3R,4R,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium | 34031-32-8 | C20H35AuO9PS+ |
|
| —— | Disodium 2-[(2-carboxylatophenyl)amino]-4-chlorobenzoate | 64808-48-6 | C14H10ClNNaO4 |
|
| —— | Fenoprofen monohydrate | 71720-56-4 | C15H16O4 |
|
| —— | N-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetyl]-serine | 57645-05-3 | C22H21ClN2O6 |
|
| —— | gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphane | 34031-32-8 | C20H34AuO9PS |
|
| —— | 4-hydroxy-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide | 71125-38-7 | C13H11N3O4S2 |
|
| —— | ketoprofen tromethamine salt | 156604-79-4 | C4H11NO3*C16H14O3 |
|
| —— | 4-(biphenyl-4-yl)-4-oxobutyric acid | 36330-85-5 | C15H12O3 |
|
| —— | Nimesulide | 51803-78-2 | C13H14N2O5S |
|
| —— | crassicauline A | 79592-91-9 | C35H49NO10 |
|
| —— | diclofenac sodium | 15307-79-6 | C14H10Cl2NO2*Na |
|
| —— | Naprelan | 26159-34-2 | C14H13O3*Na |
|
| —— | tolmetin sodium | 35711-34-3 | C15H14NO3*Na |
|
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