lithium 2-(3-cyanophenyl)-2,2-difluoroacetate | 2680540-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: lithium 2-(3-cyanophenyl)-2,2-difluoroacetate
• 英文别名: Lithium(1+) 2-(3-cyanophenyl)-2,2-difluoroacetate；lithium;2-(3-cyanophenyl)-2,2-difluoroacetate
• CAS: 2680540-61-6
• 化学式: C₉H₄F₂NO₂*Li
• 分子量: 203.074
• InChiKey: YSZUCJQZKPZDDO-UHFFFAOYSA-M

反应信息

• 作为反应物：
  描述：

  (2S)-2-amino-N-(4-((R or S)-2-methoxy-1-((S)-2-oxo-4-(trifluoromethyl)imidazolidin-1-yl)ethyl)pyridin-2-yl)-2-((1r,4S)-4-methylcyclohexyl)acetamide hydrochloride 、 lithium 2-(3-cyanophenyl)-2,2-difluoroacetate 在 1-丙基磷酸酐 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以14 mg的产率得到2-(3-cyanophenyl)-2,2-difluoro-N-((S)-2-((4-((S)-2-methoxy-1-((S)-2-oxo-4-(trifluoromethyl)imidazolidin-1-yl)ethyl)pyridin-2-yl)amino)-1-((1r,4S)-4-methylcyclohexyl)-2-oxoethyl)acetamide
  参考文献：
  名称：

  THERAPEUTIC COMPOUNDS

  摘要：

  The present disclosure relates to compounds that are IL-17A modulators. The compounds have the structural Formula I defined herein. The present disclosure also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with modulation of IL-17A activity.

  公开号：

  WO2024121427A1