1D-N,N'-bis-benzyloxycarbonyl-O⁴-(2-benzyloxycarbonylamino-O⁴,O⁶-(R)-benzylidene-α-D-ribo-2,3-dideoxy-hexopyranosyl)-O⁵-[O²,O³;O⁴,O⁶-(Ξ,R)-dibenzylidene-α-D-mannopyranosyl-(1->4)-2,6-bis-benzyloxycarbonylamino-β-L-2,6-dideoxy-idopyranosyl-(1->3)-β-D-ribofuranosyl]-2-deoxy-streptamine | 50930-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: 1D-N,N'-bis-benzyloxycarbonyl-O⁴-(2-benzyloxycarbonylamino-O⁴,O⁶-(R)-benzylidene-α-D-ribo-2,3-dideoxy-hexopyranosyl)-O⁵-[O²,O³;O⁴,O⁶-(Ξ,R)-dibenzylidene-α-D-mannopyranosyl-(1->4)-2,6-bis-benzyloxycarbonylamino-β-L-2,6-dideoxy-idopyranosyl-(1->3)-β-D-ribofuranosyl]-2-deoxy-streptamine
• CAS: 50930-06-8
• 化学式: C₉₀H₉₇N₅O₂₈
• 分子量: 1696.78
• InChiKey: BLQXWIKJEIUYLJ-IFPMILHISA-N

反应信息

• 作为反应物：
  描述：

  1D-N,N'-bis-benzyloxycarbonyl-O⁴-(2-benzyloxycarbonylamino-O⁴,O⁶-(R)-benzylidene-α-D-ribo-2,3-dideoxy-hexopyranosyl)-O⁵-[O²,O³;O⁴,O⁶-(Ξ,R)-dibenzylidene-α-D-mannopyranosyl-(1->4)-2,6-bis-benzyloxycarbonylamino-β-L-2,6-dideoxy-idopyranosyl-(1->3)-β-D-ribofuranosyl]-2-deoxy-streptamine 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1L-N¹-benzyloxycarbonyl-O⁶-(2-benzyloxycarbonylamino-O⁴,O⁶-(R)-benzylidene-α-D-ribo-2,3-dideoxy-hexopyranosyl)-N³,O⁴-carbonyl-O⁵-[O²,O³;O⁴,O⁶-(Ξ,R)-dibenzylidene-α-D-mannopyranosyl-(1->4)-2,6-bis-benzyloxycarbonylamino-β-L-2,6-dideoxy-idopyranosyl-(1->3)-β-D-ribofuranosyl]-2-deoxy-streptamine
  参考文献：
  名称：

  Synthesis of 1-N-[(S)-4-Amino-2-hydroxybutyryl]lividomycin A

  摘要：

  The title compound (7), which is active against resistant bacteria producing phosphotransferase I, was synthesized from lividomycin A through a cyclic carbamate derivative (3). Selective hydrolysis of the carbamate ring followed by acylation of the free C-1-amino group with (S)-2-hydroxy-4-aminobutyric acid by the active ester method led to 7.

  DOI：

  10.1246/bcsj.48.2124

文献信息

• SYNTHESIS OF 1-N-((s)-4-AMINO-2-HYDROXYBUTYRYL) LIVIDOMYCIN A
  作者：ISAMU WATANABE、TSUTOMU TSUCHIYA、SUMIO UMEZAWA、HAMAO UMEZAWA

  DOI：10.7164/antibiotics.26.310

  日期：——