7-(3-{4-[3-(4-Chloro-phenoxy)-propyl]-piperazin-1-yl}-2-hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; hydrochloride | 79712-38-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-(3-{4-[3-(4-Chloro-phenoxy)-propyl]-piperazin-1-yl}-2-hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; hydrochloride
• CAS: 79712-38-2
• 化学式: C₂₃H₃₁ClN₆O₄*2ClH
• 分子量: 563.912
• InChiKey: LYEMCNTUTIGJMM-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 7-(3-{4-[3-(4-Chloro-phenoxy)-propyl]-piperazin-1-yl}-2-hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; hydrochloride 在 吡啶 作用下， 生成 Acetic acid 1-{4-[3-(4-chloro-phenoxy)-propyl]-piperazin-1-ylmethyl}-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-ethyl ester
  参考文献：
  名称：

  New Antihistaminic Theophylline or Theobromine Derivatives

  摘要：

  A series of 3,4-dihydro-1,3-dimethyl-7-[3-(4-substituted-piperazin-1-yl)- substituted-alkyl]-1H-purine-2,6-diones and 3,7-dihydro-3,7-dimethyl-1-[3-(4-substituted-piperazin-1-yl)- substituted-alkyl]-1H-purine-2,6-diones was synthesized and evaluated for antihistaminic activity. Some of them displayed good inhibition of both histamine-induced bronchospasm in the anesthetized guinea pig at 10 micrograms/kg by the intravenous route and of passive cutaneous anaphylaxis in the rat at 10 mg/kg by the oral route. Comparison of the two most active compounds revealed a higher antihistaminic activity with the compounds containing a (phenylthio)propyl group (1 and 2) as compared with that containing a phenoxy group. Compound 2 [RS-49014, 3,4-dihydro-1,3-dimethyl-7-[3-[4-[3-(phenylthio)propyl]piperazin-1 -yl]- 2-hydroxypropyl]-1H-purine-2,6-dione] was selected for clinical trials on the basis of a comparative pharmacological study with chlorpheniramine, ketotifen, promethazine, and theophylline.

  DOI：

  10.1021/jm50001a019