| 132645-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 132645-23-9
• 化学式: C₂₄H₂₃N₃O₈S
• 分子量: 516.504
• InChiKey: UCPVTGXKWFXDTD-ZKQSJBIESA-N

反应信息

• 作为产物：
  描述：

  (4S,2'R)-3β-bromo-3-methyl-7β-(phenoxyacetamido)-4-spiro-4'-<2'-methoxy-2'-(p-nitrophenyl)-1',3'-dioxolane>cepham 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 苯 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Uncommon formation of spiro orthoesters in the bromomethoxylation reaction of a 4-[(aroyloxy)methyl]-3-cephem derivative

  摘要：

  The reaction of 4-[((p-nitrobenzoyl)oxy)methyl]-3-cephem derivative 4 with bromine in methanol afforded a mixture of the 3-bromo-4-methoxy adducts 5 and 6 and of the unexpected 4-spiro orthoesters 7 and 8. The structure and configuration of 7 and 8 were demonstrated through the determination of the solid-state structure of 7 and by H-1 and C-13 NMR studies and chemical transformations. The mechanism and the stereochemical outcome of the reaction are discussed.

  DOI：

  10.1021/jo00006a035