| 1254583-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• CAS: 1254583-56-6
• 化学式: C₂₂H₃₆FN₃O₆P₂
• 分子量: 519.49
• InChiKey: UEGWKECMLOTMBD-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 、 水 作用下， 生成 [1-fluoro-1-phosphono-2-[5-(1H-pyrazol-4-yl)pyridin-2-yl]ethyl]phosphonic acid
  参考文献：
  名称：

  Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase

  摘要：

  A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate sub-pockets of the enzyme are presented. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.133